PMID: 11903738Mar 21, 2002Paper

Influence of Helicobacter pylori infection on the prevalence of reflux esophagitis in Japanese patients

Journal of Gastroenterology and Hepatology
H FujishiroY Kinoshita

Abstract

Reflux esophagitis is caused by esophageal motor dysfunction in patients with sufficient gastric acid secretion. Helicobacter pylori causes atrophic gastritis and influences gastric acid secretion. Hiatus hernia (HH) of the esophagus causes motor dysfunction in the lower esophagus. Therefore, this study aimed to test whether H. pylori infection, gastric mucosal atrophy and HH are predictive factors for reflux esophagitis. Helicobacter pylori infection was examined in 781 patients by the measurement of serum immunoglobulin (Ig)G antibody, bacteriological culture and histological examination of biopsy specimens. The prevalence of HH, endoscopically identified gastric mucosal atrophy (closed- or open-type) and reflux esophagitis were investigated by reviewing endoscopic films. Investigated patients were divided into three age groups, under 49, 50-69, and over 70 years. The prevalence of esophagitis, H. pylori infection, gastric mucosal atrophy, and HH were compared to identify the possible predictive factors for reflux esophagitis by using logistic regression analysis. Sixty-nine patients with reflux esophagitis were found among the 781 investigated cases. The odds ratios of negative H. pylori infection, endoscopically identified ...Continue Reading

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Citations

Apr 28, 2005·Journal of Gastroenterology and Hepatology·Takafumi MiharaYoshikazu Kinoshita
Nov 23, 2007·Journal of Gastroenterology and Hepatology·Katsuhiko IwakiriChoitsu Sakamoto
Jul 14, 2010·Journal of Gastroenterology and Hepatology·Takashi KawaiTatsuya Aoki
Jan 14, 2011·Journal of Gastroenterology and Hepatology·Khean-Lee Goh
Nov 1, 2008·Therapeutic Advances in Gastroenterology·Yoshikazu Kinoshita, Shunji Ishihara
Apr 15, 2009·Journal of Gastroenterology·Yasuhiro Fujiwara, Tetsuo Arakawa
Apr 17, 2015·Internal Medicine·Kyoichi AdachiYoshikazu Kinoshita
Mar 7, 2015·Internal Medicine·Kozue HanadaYoshikazu Kinoshita
May 3, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kingo HirasawaShin Maeda
Jun 1, 2012·Current Therapeutic Research, Clinical and Experimental·Shino ShimuraYoshikazu Kinoshita
Mar 22, 2012·The American Journal of Gastroenterology·Yoshikazu KinoshitaUNKNOWN Japan TWICE Study Group
Sep 21, 2007·Journal of Clinical Gastroenterology·Tseng-Shing Chen, Full-Young Chang
May 22, 2019·Journal of Gastroenterology and Hepatology·Kyoichi AdachiYoshikazu Kinoshita
Oct 8, 2005·Scandinavian Journal of Gastroenterology·Ikuyo MishimaYoshikazu Kinoshita

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Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.