Influence of hemoglobin phenotype on the mean erythrocyte volume

Acta Haematologica
R G Sheehan, E P Frenkel

Abstract

The influence of the hemoglobin (Hgb) phenotype on mean erythrocyte volume was re-examined in the light of recent evidence indicating a poor correlation between manual and more precise automated methods of measurement. The present studies identified a 17.6% frequency of microcytosis in a population of nonanemic Black males, a value higher than previously appreciated. In addition, it was shown that the frequency of microcytosis was also a function of the Hgb phenotype. Thus, 9.4% of Hgb AA, 18.6% of AS and 26.5% of AC subjects had microcytic erythrocytes. The data presented are consistent with the hypothesis that both the alpha-gene complement and the beta-chain phenotype contribute to the erythrocytic mean corpuscular volume and that the frequency of microcytosis in a patient population is a function of both of these variables.

Citations

Apr 14, 2006·British Journal of Haematology·Sammy WambuaThomas N Williams
May 6, 2015·Tropical Medicine & International Health : TM & IH·Sophie A MüllerFrank P Mockenhaupt
Aug 3, 2013·Journal of Feline Medicine and Surgery·Saverio PaltrinieriGabriele Rossi
Jul 28, 2020·Animals : an Open Access Journal From MDPI·Arianna MiglioMaria Teresa Antognoni

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