Influence of Hepatic Inflammation on FibroScan Findings in Diagnosing Fibrosis in Patients with Chronic Hepatitis B

Ultrasound in Medicine & Biology
Xianghua ZengYuming Wang

Abstract

Hepatic inflammation may affect the performance of FibroScan. This prospective study investigated the influence of hepatic inflammation on liver stiffness measurement (LSM) values by assessing FibroScan and liver biopsy findings in 325 patients with chronic hepatitis B. Liver fibrosis and inflammation were classified into five stages (S0-S4) and grades (G0-G4) according to the Scheuer scoring system. LSM values were correlated with fibrosis stage and inflammation grade (r = 0.479, p < 0.001, and r = 0.522, p < 0.001, respectively). Although LSM values increased in parallel with inflammation grade, no significant differences were found between patients with significant fibrosis (S2-S4) (p > 0.05). For inflammation grades G0, G1, G2 and G3, areas under receiver operating characteristic curves of FibroScan for significant fibrosis were 0.8267 (p < 0.001), 0.6956 (p < 0.001), 0.709 (p = 0.0012) and 0.6947 (p = 0.137), respectively. Inflammation has a significant influence on LSM values in patients with chronic hepatitis B with mild fibrosis, but not in those with significant fibrosis.

References

Nov 1, 1991·Journal of Hepatology·P J Scheuer
Feb 15, 2001·The New England Journal of Medicine·A A BravoS Chopra
Jun 30, 2001·The New England Journal of Medicine·S MirzaeiH Kohn
Dec 31, 2003·Ultrasound in Medicine & Biology·Laurent SandrinRobert Palau
May 31, 2006·Gastroentérologie Clinique Et Biologique·Michel Beaugrand
Apr 4, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Faisal M SanaiKhalid I Bzeizi
Jul 19, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Patrick MarcellinMichel Beaugrand
Sep 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ze-Zhou Song
Nov 21, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Seung Up KimDo Young Kim
May 22, 2009·Journal of Gastroenterology and Hepatology·Grace L-H WongHenry L-Y Chan
Aug 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S F Lok, Brian J McMahon
Jan 12, 2010·Scandinavian Journal of Gastroenterology·Yeon Seok SeoSoon Ho Um
Aug 28, 2010·Journal of Gastroenterology and Hepatology·Kun ZhouLun-Gen Lu
May 21, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Raffaele BrunoGaetano Filice
Apr 10, 2012·Bulletin of Experimental Biology and Medicine·A V KudryashovV V Lyakhovich
Mar 30, 2013·Journal of Pediatric Gastroenterology and Nutrition·Imeke GoldschmidtUlrich Baumann
Jul 3, 2013·Journal of Gastroenterology and Hepatology·Rohit GoyalSubrat K Acharya
Oct 10, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Paul CalèsUNKNOWN ANRS HC EP 23 Fibrostar Study
May 17, 2014·Medical Devices : Evidence and Research·Julius Wilder, Keyur Patel
Aug 21, 2014·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Praveen SharmaAnil Arora
Oct 17, 2014·Clinical and Molecular Hepatology·Grace Lai-Hung Wong

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Citations

Oct 31, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Sebastian BernuthTim Zimmermann
Oct 30, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Akira OkajimaYoshito Itoh
Nov 28, 2019·Journal of Clinical Medicine·Jeong-Ju YooSang Gyune Kim

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