Influence of hexabromocyclododecane and 4-nonylphenol on the regulation of cell growth, apoptosis and migration in prostatic cancer cells

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Seung-Hee KimKyung-Chul Choi

Abstract

The aim of the present study was to determine whether hexabromocyclododecane (HBCD) or 4-nonylphenol (NP) may induce prostatic cancer progression in LNCaP cells. Androgenic effects of HBCD and NP were examined in LNCaP prostate cancer cells expressing androgen receptors (ARs). HBCD and NP increased LNCaP cell viability similar to dihydrotestosterone (DHT) by MTT assay. This phenomenon was reversed by treatment with Casodex, an AR antagonist, suggesting that they act as xenoandrogens via AR signaling pathway. In cell migration assay, HBCD and NP also enhanced LNCaP cell migration similar to DHT. To elucidate underlying mechanisms of their actions on LNCaP, transcriptional levels of cell cycle- and apoptosis-related markers, including cyclin D1, cyclin E, p27, bcl-2, and bax, were determined by reverse transcription (RT)-PCR. An increase in expression cyclin D1 and cyclin E and reduction in p27 and bax mRNA levels were observed by their treatments. Western blot assay showed their alterations in translational levels of cyclin D1, cyclin E, p21, bax, and cathepsin D. Expressions of genes related to a G1/S transition of cell cycle and cathepsin D were elevated, while expression of p21 and bax was decreased. Taken together, these res...Continue Reading

References

Dec 16, 1994·Science·L H Hartwell, M B Kastan
Apr 16, 1998·Environmental Health Perspectives·T M CrispY M Patel
May 20, 1999·Annual Review of Pharmacology and Toxicology·D G Johnson, C L Walker
Aug 13, 1999·Genes & Development·A GrossS J Korsmeyer
Jun 19, 2001·Molecular and Cellular Endocrinology·C SultanJ Nicolas
May 8, 2002·Environmental Science & Technology·Klaus GuentherTorsten Raecker
May 6, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·George P DastonRobert J Kavlock
Jun 14, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hyun Ju LeeKeesook Lee
Oct 21, 2004·Cancer·David G BostwickBarry Timms
Nov 19, 2004·Nature·Michael B Kastan, Jiri Bartek
Dec 14, 2004·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Seul Min Choi, Byung Mu Lee
Jul 28, 2005·Cancer Letters·Emmanuelle Liaudet-CoopmanFrançoise Vignon
Nov 22, 2005·Cancer Letters·J K Hess-Wilson, K E Knudsen
Jul 13, 2006·Environmental Science & Technology·Adrian CovaciJacob De Boer
May 22, 2007·Environment International·Yu-Yu LuI-Fang Mao
Sep 8, 2007·Environmental Science & Technology·Cathrine ThomsenErik Dybing
Jan 12, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Calvin C WillhiteClifton J McLellan
Feb 26, 2008·Toxicology·Tanja KrügerEva C Bonefeld-Jørgensen
Apr 9, 2008·Critical Reviews in Oncology/hematology·Petr BenesMartin Fusek
Apr 16, 2008·Environment International·N AdemolloE Funari
Jun 9, 2009·Endocrine Reviews·Evanthia Diamanti-KandarakisAndrea C Gore
Oct 10, 2009·The Science of the Total Environment·Cynthia A de WitKatrin Vorkamp
Dec 24, 2010·World Journal of Surgical Oncology·Michael StamatakosKonstantinos Kontzoglou
Sep 9, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Thaddeus T SchugJerrold J Heindel
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Sep 24, 2013·Journal of Toxicology and Environmental Health. Part a·Candace RobledoJean R Goodman
Dec 1, 2010·Toxicological Research·Eui-Bae Jeung, Kyung-Chul Choi
Jul 12, 2014·BioMed Research International·Mohamed HassanNoriaki Sakuragi
Sep 11, 2014·Journal of Cellular Physiology·Anita Roy, Subrata Banerjee
Mar 4, 2015·Journal of Toxicology and Environmental Health. Part a·Jiaqin BaoBo Chen

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Citations

Jun 5, 2016·Toxicology·Maurizio ForteMaria De Falco
Jun 29, 2017·Molecular Medicine Reports·Xuefeng YangMing Xie
May 30, 2020·International Journal of Molecular Sciences·Vidhya A NairWael M Abdel-Rahman
May 18, 2019·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ming XieXue-Feng Yang
Mar 19, 2021·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Christiane Vleminckx

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