PMID: 8584309Oct 1, 1995Paper

Influence of high titers of maternal antibody on the serologic response of infants to diphtheria vaccination at three, five and twelve months of age

The Pediatric Infectious Disease Journal
B BjörkholmL Hagberg

Abstract

Diphtheria antitoxin was determined in serum from 44 pregnant women, of whom 26 had received one injection of diphtheria toxoid during pregnancy. Their infants were vaccinated with a combined diphtheria-tetanus vaccine at 3, 5 and 12 months of age. This vaccination schedule has been used in Sweden since 1986, replacing the old schedule of vaccination at 3, 4.5 and 6 months of age originally designed for diphtheria-tetanus-pertussis vaccine, which had not been used after cessation of general vaccination against pertussis in 1979. Serum samples from the infants were obtained at 3, 7 and 18 months of age. After 2 injections infants of mothers with high antitoxin titers, > or = 0.1 IU/ml, tended to have lower antitoxin titers than infants of mothers with low antitoxin concentrations (P = 0.067). All children had, however, antitoxin above the minimum protective level of 0.01 IU/ml. Median antitoxin titers were 1.6 IU/ml in both groups after the third booster injection. Four infants of mothers who had been vaccinated during pregnancy and who had titers of > or = 0.4 IU/ml did not reach the 0.1 IU/ml level after 2 injections: all 4 responded with high antitoxin titers after the third dose. Thus all infants were primed by 2 doses of va...Continue Reading

Citations

May 12, 2001·Vaccine·C A Siegrist
Jul 2, 2004·Nature Reviews. Immunology·Becky AdkinsStuart Marshall-Clarke
Feb 28, 2002·Clinical Obstetrics and Gynecology·Roger G Faix
Dec 26, 2009·The Journal of Veterinary Medical Science·Mohamed Fahmy Abou ElazabShuichi Furusawa
Jan 1, 2009·Immunotherapy·Paula Ordonhez RigatoMaria Notomi Sato
Sep 15, 2015·Human Vaccines & Immunotherapeutics·Azure N FaucetteKang Chen
Oct 14, 2014·Frontiers in Microbiology·Jorjoh Ndure, Katie L Flanagan
Apr 14, 2000·International Reviews of Immunology·C A Siegrist
Mar 9, 2012·International Archives of Allergy and Immunology·Jitka S HansenMartinus Lovik
Mar 20, 2013·Current Opinion in Infectious Diseases·Benjamin LindseyChristine Jones
Sep 12, 2019·Frontiers in Nutrition·Shireen Nigar, Takeshi Shimosato

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