Influence of hindlimb unweighting and intermittent weight bearing on dynamics of nuclei in rat soleus muscle

Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō
Toshiaki Yamazaki

Abstract

The purpose of this study was to examine differences in the inhibitory effect of disuse atrophy as a result of intermittent weight bearing in terms of the dynamics of nuclei in rat soleus muscle. Disuse muscle atrophy was induced by hindlimb suspension for two weeks. Forty-nine male Wistar rats (body weight: 190-228 g) were divided into the control group (CON) and the experimental group. The experimental group was subdivided into four groups: hindlimb suspension alone (HS), weight bearing for 10 minutes × 4 times/day (W10), weight bearing for 20 minutes × 2 times/day (W20), and weight bearing for 40 minutes × one time/day (W40). In addition to histochemical examination, this study examined both cell proliferation and apoptosis in terms of the dynamics of myonuclei immuno-histochemically. The mean cross-sectional area of muscle fibers demonstrated the effect of weight bearing. The number of proliferating myonuclei per 100 muscle fibers was decreased in the experimental groups as compared with CON. Proliferating myonuclei in W10 and W40 were more than HS, indicating the effect of weight bearing. Apoptotic myonuclei was increased in the experimental groups as compared with CON. This parameter in W10 and W40 were statistically not ...Continue Reading

References

Feb 1, 1992·Journal of Applied Physiology·D S D'AunnoF W Booth
Oct 1, 1990·Journal of Applied Physiology·D S D'AunnoF W Booth
Nov 1, 1989·Journal of Applied Physiology·K C Darr, E Schultz
Jul 1, 1987·Journal of Applied Physiology·D B ThomasonK M Baldwin
May 1, 1995·Journal of Applied Physiology·D L AllenV R Edgerton
Jun 1, 1995·Archives of Physical Medicine and Rehabilitation·M Brown, E M Hasser
Jan 1, 1994·Journal of Applied Physiology·E SchultzA Macius
Jan 1, 1993·Muscle & Nerve·B B Krippendorf, D A Riley
Jan 1, 1997·Archives of Physical Medicine and Rehabilitation·K A Alley, L V Thompson
Aug 1, 1997·The American Journal of Physiology·D L AllenV R Edgerton
Sep 17, 1999·Muscle & Nerve·D L AllenV R Edgerton
Jan 1, 1998·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·T YamazakiK Tachino
Jan 1, 2001·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·T YamazakiK Tachino

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Citations

Jan 1, 2005·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·Toshiaki Yamazaki
Jan 1, 2009·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·Toshiaki YamazakiKatsuhiko Tachino
May 2, 2014·PloS One·Irina V OgnevaIrina M Larina
Dec 18, 2013·Archives of Physical Medicine and Rehabilitation·Kelli G SharpStephen J Page
Jan 1, 2012·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·Kazumi Zushi, Toshiaki Yamazaki

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