Influence of histidine on the release of all-trans retinoic acid from self-assembled glycol chitosan nanoparticles

Drug Development and Industrial Pharmacy
Chang-Moon LeeKi-Young Lee

Abstract

In this study, the influence of N-acetyl histidine (NAHis) on the all-trans retinoic acid (ATRA) release from the NAHis-conjugated self-assembled glycol chitosan (GC) nanoparticles was investigated. NAHis was conjugated to GC as a hydrophobic moiety to prepare the self-assembled nanoparticles, and ATRA was incorporated into the inner core of the NAHis-GC nanoparticles. The ATRA release from NAHis-GC nanoparticles was performed at 37 degrees C in a phosphate-buffered saline buffer (pH 5.5 or 7.4) for 48 hours. At a pH of 5.5, less than 20% (w/w) of total loading amount of ATRA was released from the nanoparticles after 48 hours. In contrast, two times greater amount of ATRA was released at a pH of 7.4. The ATRA release rate from the NAHis-GC nanoparticles was significantly slower at a pH of 5.5 than at a pH of 7.4. The release profiles of ATRA that was incorporated into the NAHis-GC nanoparticles were controlled by the NAHis content in the GC nanoparticles.

References

May 29, 1995·International Journal of Cancer. Journal International Du Cancer·G KrupitzaC Dittrich
Jul 5, 2005·Expert Opinion on Investigational Drugs·M Pfahl
Oct 19, 2005·Biotechnology Letters·Chang-Moon LeeKi-Young Lee
Mar 11, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jun-Pil JeeChong-Kook Kim
Aug 4, 2006·Journal of Pharmaceutical Sciences·Young-Il JeongShin Jung
Aug 16, 2006·Drug Development and Industrial Pharmacy·X ZhangN Gu
Aug 29, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ji Sun ParkYong Woo Cho
Feb 20, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Praneet OpanasopitSuwabun Chirachanchai
Jun 21, 2007·Journal of Microencapsulation·Gisele A CastroLucas A M Ferreira
Feb 6, 2008·International Journal of Pharmaceutics·A F OuriqueR C R Beck
Mar 14, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kyung Hyun MinIck Chan Kwon
Jul 29, 2008·International Journal of Pharmaceutics·Sagar D Mandawgade, Vandana B Patravale
Jan 13, 2009·Colloids and Surfaces. B, Biointerfaces·Dong-Hyuk SeoJae-Woon Nah
Jun 2, 2009·International Journal of Pharmaceutics·Adriana TrapaniThomas Kissel

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Citations

Jul 28, 2012·Therapeutic Delivery·Thi Ngoc Tram DoRamin Rohanizadeh
May 3, 2014·Drug Development and Industrial Pharmacy·Xiu-Rong ZhangYing Jin
Jul 24, 2012·Biomaterials·Luca CasettariLisbeth Illum
Jun 15, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Il-Kyu ParkYong-Kyu Lee

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