Influence of hormone replacement therapy on the accuracy of screening mammography

The Breast Journal
María del Mar VernetRamón Carreras

Abstract

The use of hormone replacement therapy (HRT) is currently a subject of debate because of the possibility of an increase in the incidence of breast cancer and difficulties associated with breast cancer detection. The objective of this study was to determine the influence of HRT on specificity and sensitivity in a breast cancer screening program. We found that although specificity was significantly lower in menopausal women who had ever used or were currently using HRT (93.3%) compared to HRT nonusers (94.8%) at the expense of a greater number of recalls (6.9% versus 5.6%), this difference seems to be clinically irrelevant. There were no significant differences with regard to the number of invasive procedures (2.5% in the HRT versus 2.1% in the control group). We conclude that the slight decrease in sensitivity of screening mammography in HRT users is not clinically significant in our setting, and in any case, false positives (recalled women) are diagnosed correctly with additional imaging studies without the need for invasive procedures. Most women given HRT are candidates to participate in population breast cancer screening campaigns.

References

Aug 3, 1989·The New England Journal of Medicine·L BergkvistC Schairer
Nov 15, 1997·Journal of the National Cancer Institute·J A HarveyC R Herman
Feb 5, 2000·JAMA : the Journal of the American Medical Association·C SchairerR Hoover
Feb 17, 2000·Journal of the National Cancer Institute·R K RossM C Pike
Feb 13, 2001·Journal of Epidemiology and Community Health·C KlabundeUNKNOWN International Breast Cancer Screening Network (IBSN)
Apr 23, 2002·American Journal of Obstetrics and Gynecology·Eva LundströmBo von Schoultz
Jul 5, 2002·Clinical Radiology·A Evans
Aug 21, 2002·Academic Radiology·Caroline E BlaneIngvar Andersson
Sep 7, 2002·Archives of Surgery·Julie CheekRodney F Pommier
Mar 4, 2003·Postgraduate Medicine·Kim Cardenas, Kelly Frisch
May 27, 2003·Postgraduate Medicine
Jun 26, 2003·JAMA : the Journal of the American Medical Association·Rowan T ChlebowskiUNKNOWN WHI Investigators
Aug 21, 2003·Lancet·Valerie Beral, UNKNOWN Million Women Study Collaborators
Jan 21, 2004·The Breast : Official Journal of the European Society of Mastology·J C Litherland

❮ Previous
Next ❯

Citations

Apr 24, 2010·Breast Cancer Research and Treatment·Brian CoxUNKNOWN International Cancer Screening Network
Jul 26, 2013·Radiology·Jason RothschildMartha B Mainiero
Apr 25, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Samina KhokherAfaf Saleem
Mar 1, 2016·Journal of the American College of Radiology : JACR·Jeffrey R HawleySelin Carkaci

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pharmacoepidemiology and Drug Safety
Ilona CsizmadiAndrea Benedetti
Revista da Associação Médica Brasileira
Sílvia E V ZaharFábio Russomano
Climacteric : the Journal of the International Menopause Society
A H MacLennanA W Taylor
American Journal of Obstetrics and Gynecology
Denise M Lochner, Katherine L Brubaker
© 2021 Meta ULC. All rights reserved