PMID: 9442288Jan 27, 1998Paper

Influence of hormones and hormone antagonists on sexual differentiation of the brain

Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement
K D Döhler

Abstract

In summary, a number of studies have shown that not only estrogenic and androgenic steroids and their antagonists influence sexual differentiation of the mammalian brain but also drugs which stimulate or inhibit the adrenergic, the serotoninergic, or the cholinergic system in the developing brain. The present knowledge on the possible participation of neurotransmitter systems in sexual differentiation of the brain and their mode of interaction in this process perinatally with gonadal steroids is still rather limited. Sexual differentiation of the central nervous system is a complex integrated process, which relies on proper chronological and quantitative interactions of various endocrine and neuroendocrine mediators. Any disturbance of this delicate endogenous hormonal balance during ontogenetic development, e.g. by means of environmental influences, can result in permanent manifestation of anatomic and functional sexual deviations. A large number of man-made chemicals that have been released into the environment have the potential to disrupt the endocrine system of animals and humans. They do so because they mimick the effects of natural hormones or neurotransmitters by recognizing their binding sites, or they antagonize the e...Continue Reading

Citations

May 26, 2007·Reproduction, Fertility, and Development·Chae Kwan LeeSung Goo Kang
Sep 2, 2009·The Journal of Reproduction and Development·Masatoshi SuzukiMasugi Nishihara
Jun 17, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Gregg D CapponLeigh Ann Burns-Naas
Dec 1, 2000·Human Nature : an Interdisciplinary Biosocial Perspective·J C Stevenson, D C Williams

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