Influence of human biokinetics of strontium on internal ingestion dose of 90Sr and absorbed dose of 89Sr to organs and metastases.

Radiation and Environmental Biophysics
Wei Bo LiU Oeh

Abstract

The objective of the present work is to apply the plasma clearance parameters to strontium, previously determined in our laboratory, to improve the biokinetic and dosimetric models of strontium-90 ((90)Sr) used in radiological protection; and also to apply this data for the estimation of the radiation doses from strontium-89 ((89)Sr) after administration to patients for the treatment of the painful bone metastases. Plasma clearance and urinary excretion of stable strontium tracers of strontium-84 ((84)Sr) and strontium-86 ((86)Sr) were measured in GSF-National Research Center for Environment and Health (GSF) in 13 healthy German adult subjects after intravenous injection and oral administration. The biological half-life of strontium in plasma was evaluated from 49 plasma concentration data sets following intravenous injections. This value was used to determine the transfer rates from plasma to other organs and tissues. At the same time, the long-term retention of strontium in soft tissue and whole body was constrained to be consistent with measured values available. A physiological urinary path was integrated into the biokinetic model of strontium. Parameters were estimated using our own measured urinary excretion values. Reten...Continue Reading

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Citations

Aug 13, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Massimiliano PacilioLucio Mango
Oct 17, 2015·Nutrition and Cancer·Geir Bjørklund
Aug 12, 2010·Health Physics·Tatiana G LevitskaiaKarla D Thrall
Aug 13, 2010·Nihon Hoshasen Gijutsu Gakkai zasshi·Hitomi OdaMasahiro Kubota
Sep 21, 2020·Radiation and Environmental Biophysics·Vladimir SpielmannNina Petoussi-Henss
Feb 14, 2013·Experimental and Therapeutic Medicine·Wenjie ZhangHoufu Deng

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