PMID: 36049May 1, 1979

Influence of hydrogen ion concentration on bile acid induced acute gastric mucosal ulcerogenesis

Annals of Surgery
W P Ritchie, K J Cherry

Abstract

Aggressive treatment with H(2) receptor blocking agents and/or antacids has been advocated as effective prophylaxis against and treatment for "stress ulcer," based on the logical but infrequently tested assumption that the severity of the disease is critically determined by the concentration of intraluminal acid. The present study investigated this assumption in a model which employed topical acid, topical bile acid and mucosal ischemia to induce ulcerogenesis. With vascularized, chambered ex vivo wedges of canine proximal gastric wall, groups of animals were studied during three sequential periods using topical test solutions (TS) containing either 0 mM, 100 mM or 160 mM HCI. During period 1, mucosae were exposed to TS alone; during period 2, either to TS containing 1 mM sodium taurocholate (TC) or to TS and concomitant vasopressin infusion (VP); and during period 3, to TS + TC + VP. Parameters evaluated included net H(+) flux ( big up tri, openH(+)), aminopyrine clearance (AC), a measure of mucosal blood flow, net TC flux ( big up tri, openTC) and the lesion index, graded 0-5. The data indicate that in nonischemic mucosa exposed to constant [TC], AC was significantly increased, big up tri, openH(+) ("back-diffusion") increase...Continue Reading

References

Mar 1, 1981·World Journal of Surgery·W P Ritchie
Nov 1, 1980·The Journal of Clinical Investigation·W C Duane, D M Wiegand

Citations

Oct 1, 1976·Annals of Surgery·S J Simonian, L E Curtis
Jan 1, 1978·American Journal of Surgery·R J StraussL Wise
Aug 1, 1976·The Journal of Trauma·J C McAlhanyB A Pruitt
Jan 1, 1976·American Journal of Surgery·J F Stremple
May 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·L A Turnberg, A Anthony-Mote
Jul 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·S Safaie-ShiraziK N Hamza
Jan 1, 1966·The Journal of Clinical Investigation·E D JacobsonM I Grossman

Related Concepts

Taurocholic Acid, Monolithium Salt
Ischemia
Bile Acid Measurement
Hydrogen Ion Concentration Measurement
Gastric Ulcer
Mucositis
Pitressin
Antidiuretic Hormone Measurement
OR2T4
Structure of Pyloric Gland

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