Influence of hydrostatic pressure on intracoronary indices of stenosis severity in vivo

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Tobias HärleAlbrecht Elsässer

Abstract

An influence of hydrostatic pressure on intracoronary indices of stenosis severity in vitro was recently reported. We sought to analyze the influence of hydrostatic pressure, caused by the height difference between the distal and proximal pressure sensor after guidewire positioning in the interrogated vessel, on intracoronary pressure measurements in vivo. In 30 coronary stenoses, intracoronary pressure measurements were performed in supine, left, and right lateral patient position. Height differences between the distal and proximal pressure sensor were measured by blinded observers. Measurement results of the position with the highest ("high") and lowest height difference ("low") were compared. In group "high", all measured indices were higher: mean difference of fractional flow reserve (FFR) 0.045 (SD 0.033, 95% CI 0.033-0.057, p < 0.0001), of instantaneous wave-free ratio (iFR) 0.043 (SD 0.04, 95% CI 0.029-0.057, p < 0.0001), and of resting Pd/Pa 0.037 (SD 0.034, 95% CI 0.025-0.049, p < 0.0001). Addition of the physically expectable hydrostatic pressure to the distal coronary pressures of the control group abolished the differences: corrected ∆FFR - 0.006 (SD 0.027, 95% CI - 0.015 to 0.004, p = 0.26), corrected ∆Pd/Pa - 0.00...Continue Reading

References

Sep 1, 1987·Journal of Applied Physiology·H Hinghofer-Szalkay, J E Greenleaf
Mar 1, 1986·Journal of Applied Physiology·H Hinghofer-Szalkay
Dec 1, 1985·Journal of Applied Physiology·H Hinghofer-Szalkay
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Aug 25, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Ricardo PetracoJustin E Davies
Jul 17, 2015·International Journal of Cardiology·Tobias HärleAlbrecht Elsässer
Jul 26, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Tobias HärleAlbrecht Elsässer
Sep 8, 2016·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Tobias HärleAlbrecht Elsässer
Apr 4, 2017·JACC. Cardiovascular Interventions·Tobias HärleAlbrecht Elsässer

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Citations

Aug 18, 2020·The International Journal of Cardiovascular Imaging·Áron ÜvegesZsolt Kőszegi
May 24, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Alexander LautenAnnette Moter

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