Influence of hyperbaric oxygen on the initial stages of bone healing

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Flaviana Soares RochaPaula Dechichi

Abstract

The objective of this study was to evaluate, in a rat model, the effect of hyperbaric oxygen (HBO) on the healing of normal bone on day 7. Forty male rats were used, equally divided into two groups based on treatment and time of sacrifice: the control group had bone defects created; and the HBO group had bone defects and received HBO. HBO sessions were conducted daily, at 2.5 atmosphere absolute for 90 minutes, and the animals were euthanized after 1, 3, 5, or 7 days. Bone density, bone neoformation, and expression of Runt-related transcription factor 2 (Runx2) and tartrate-resistant acid phosphatase were evaluated. Computed tomography analysis revealed significant differences only at 3 days (P=.01) between the control and HBO groups. HBO treatment accelerated the initial events of bone repair, resulting in improved bone neoformation. Increased expression of Runx2 was observed, especially on days 5 and 7 in the HBO group, although not significantly. There was no significant difference (P=.74) in the number of tartrate-resistant acid phosphatase-positive osteoclasts between the control and HBO groups on day 7. These results suggest that exposure to HBO enhances bone anabolism, reduces inflammation, and accelerates bone healing, ...Continue Reading

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Citations

Apr 12, 2016·Oral Diseases·P CeponisJ J Freiberger
Mar 18, 2020·Minerva stomatologica·Luiz H FerreiraFlaviana S Rocha
Jan 31, 2018·Connective Tissue Research·Pâmella Coelho DiasPaula Dechichi
Feb 17, 2018·PloS One·Pedro Henrique Justino Oliveira LimirioPaula Dechichi

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