PMID: 2492005Jan 1, 1989Paper

Influence of hyperglycemia on blood perfusion of autotransplanted pancreatic islets in diabetic rats

Diabetes
L Jansson, S Sandler

Abstract

One week after a partial pancreatectomy, which did not affect glucose homeostasis, adult rats were autotransplanted with 500 isolated pancreatic islets beneath the renal capsule. Some rats were rendered diabetic with streptozocin (STZ) before being implanted with the islets, and other rats received no STZ and thus remained normoglycemic. The number of implanted islets was insufficient to revert hyperglycemia, but the STZ-induced diabetic animals were treated with insulin according to one of the following protocols: 1) one daily subcutaneous insulin injection for 28 days after transplantation; 2) insulin injection on days 1-14; 3) insulin injection on days 15-28; or 4) no insulin. Four weeks after transplantation, the blood perfusion of the islet grafts was determined by a microsphere technique. Continuous hyperglycemia after implantation of the islets significantly decreased the volume of the graft and the blood flow per volume compared with normoglycemic animals also receiving islet transplants. Insulin treatment counteracted the decrease in both of these values. This result was achieved regardless of whether the insulin treatment was maintained throughout the 4-wk period or only during the first or second half. The mechanism ...Continue Reading

Citations

Oct 1, 1992·The Journal of Clinical Investigation·M D MengerK Messmer
Apr 1, 1995·Journal of Endocrinological Investigation·F Purrello, D Pipeleers
Apr 18, 2007·Cell Transplantation·Juliet A Emamaullee, A M James Shapiro
Jul 1, 1990·The American Journal of Physiology·L Jansson, S Sandler
Jan 1, 2007·Cell Transplantation·Juliet A Emamaullee, A M James Shapiro
Apr 28, 2000·Cell Transplantation·J F MerinoE Montanya
Mar 1, 1992·Archives of Biochemistry and Biophysics·Y GotoT Kono

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