Abstract
Soluble interleukin-2 receptor (sIL-2R), eosinophil cationic protein (ECP), the lymphoproliferative response to house-dust mite (HDM), adhesion to human umbilical vein endothelial cells (HUVEC), and lymphocyte membrane markers were studied in three groups of children: healthy children, asthmatic children without hyposensitization (HS), and asthmatic children with HS. HS was associated with significantly lower numbers of peripheral blood eosinophils (PBE) and lower sIL-2R serum levels and with a tendency to lower ECP serum levels and lymphoproliferative response to HDM. There were no changes in the T-lymphocyte phenotypic markers CD4 and CD8 among the three groups. The interleukin-2 receptor (IL-2R, CD25) on HDM-stimulated T lymphocytes increased over unstimulated T lymphocytes in the three groups. The CD25 expression was higher on HDM-stimulated lymphocytes in both asthmatic groups than in healthy children. Adhesion of lymphocytes on HUVEC increased significantly after HDM stimulation in asthmatic children without HS, whereas no change was observed in the two other groups. However, there was no change in the expression of adhesion molecules CD29 and CD11a on lymphocytes in either of the groups. This study provides further evide...Continue Reading
References
Oct 28, 1978·Lancet·J O WarnerE N Hey
Dec 1, 1976·Archives of Disease in Childhood·J O Warner
Nov 1, 1977·British Journal of Haematology·P VengeI Olsson
Mar 1, 1992·Clinical and Experimental Immunology·D MaurerW Knapp
Feb 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T SugaiS Matumoto
Dec 1, 1991·The Journal of Allergy and Clinical Immunology·S RakP Venge
Dec 1, 1991·The Journal of Allergy and Clinical Immunology·C WalkerK Blaser
Feb 1, 1991·The Journal of Allergy and Clinical Immunology·E GriffinP Venge
Jan 1, 1991·International Archives of Allergy and Applied Immunology·A B Kay
Aug 2, 1990·Nature·T A Springer
Jul 1, 1991·The Journal of Allergy and Clinical Immunology·M J FurinR M Naclerio
Jan 1, 1990·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·L C TsaiS J Tsai
Jul 1, 1990·The American Review of Respiratory Disease·E AdelrothP Venge
Sep 1, 1990·The Journal of Allergy and Clinical Immunology·J BousquetF B Michel
Nov 1, 1990·The Journal of Allergy and Clinical Immunology·S RakP Venge
Mar 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J Kus
Dec 1, 1989·The Journal of Allergy and Clinical Immunology·S R DurhamA B Kay
Apr 1, 1987·The Journal of Allergy and Clinical Immunology·R TamirR E Rocklin
May 1, 1988·Journal of Clinical Immunology·K H Hsieh
Sep 1, 1988·The Journal of Allergy and Clinical Immunology·S RakP Venge
Feb 1, 1988·Allergy·J M CavaillonB David
Nov 1, 1988·Cytometry·I SchmidJ V Giorgi
Jul 1, 1988·Allergy·H P Van BeverW J Stevens
Aug 1, 1985·Allergy·W J StevensC H Bridts
Nov 1, 1973·The Journal of Clinical Investigation·E A JaffeC R Minick
May 29, 1980·The New England Journal of Medicine·R E RocklinK L Melmon
Sep 1, 1981·The Journal of Allergy and Clinical Immunology·M HirataniM Kasei
May 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M RicciA Matucci
Citations
Apr 6, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R B Tang, S J Chen
Oct 2, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H P van BeverW J Stevens
Jan 1, 1994·Lung·J C VirchowH Matthys