PMID: 8596703Feb 1, 1996Paper

Influence of hypoxia on hepatic and renal endothelin gene expression

Pflügers Archiv : European journal of physiology
T RitthalerA Kurtz

Abstract

This study aimed to investigate the influence of different forms of tissue hypoxia on the expression of the endothelin genes in kidneys and livers. Tissue hypoxia in rats was induced by five different manoeuvres, namely hypoxia (8% O2), functional anaemia (0.1% CO), haemorrhage (haematocrit, hct = 0.12), cobalt treatment (60 mg/kg) for 6 h each and renal artery stenosis (0.2-mm clips) for 2 days. Endothelin-1 (ET-1) mRNA levels in the kidneys were increased by 200% with renal artery stenosis, 70% by hypoxia, 50% by anaemia, 30% by CO, but were not changed by cobalt. ET-3 mRNA in the kidneys decreased during renal artery clipping and cobalt treatment and were not significantly changed under the other conditions. ET-2 mRNA was not detected in the kidneys and livers. The abundance of ET-1 in the livers of normoxic animals was about 15% of that found in the kidney. Hypoxia increased ET-1 mRNA by 200%, haemorrhage by 400%, whilst CO and cobalt did not change hepatic ET-1 gene expression. The abundance of ET-3 mRNA in the livers of normoxic animals was about 6% of that found in the kidneys. The expression of the ET-3 gene in the livers was decreased by CO, but was not changed by any of the other experimental conditions used. These fi...Continue Reading

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Citations

Feb 22, 2014·International Journal of Molecular Sciences·Richard SchäferLusine Danielyan
Feb 1, 1997·Kidney International·B K KrämerA Kurtz
Jan 17, 2002·The Urologic Clinics of North America·L Lerman, S C Textor
Dec 23, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F SchwedaB K Krämer
Sep 4, 1999·Endothelium : Journal of Endothelial Cell Research·A G MinchenkoA M Lefer
Oct 24, 2002·Blood·Neil M MatsuiStephen H Embury
Jun 6, 2003·American Journal of Physiology. Renal Physiology·Richard Debigaré, S Russ Price
Jul 4, 2003·Canadian Journal of Physiology and Pharmacology·Thérèse Perreault, Flavio Coceani
Feb 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·F C BlumbergM Pfeifer
Oct 23, 2002·Journal of Applied Physiology·Friedrich C BlumbergMichael Pfeifer
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A LuchnerJ C Burnett
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·B H PannenK K Geiger
Jul 15, 1999·Journal of the American Society of Nephrology : JASN·L O LermanJ C Romero

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