Abstract
This study aimed to investigate the influence of different forms of tissue hypoxia on the expression of the endothelin genes in kidneys and livers. Tissue hypoxia in rats was induced by five different manoeuvres, namely hypoxia (8% O2), functional anaemia (0.1% CO), haemorrhage (haematocrit, hct = 0.12), cobalt treatment (60 mg/kg) for 6 h each and renal artery stenosis (0.2-mm clips) for 2 days. Endothelin-1 (ET-1) mRNA levels in the kidneys were increased by 200% with renal artery stenosis, 70% by hypoxia, 50% by anaemia, 30% by CO, but were not changed by cobalt. ET-3 mRNA in the kidneys decreased during renal artery clipping and cobalt treatment and were not significantly changed under the other conditions. ET-2 mRNA was not detected in the kidneys and livers. The abundance of ET-1 in the livers of normoxic animals was about 15% of that found in the kidney. Hypoxia increased ET-1 mRNA by 200%, haemorrhage by 400%, whilst CO and cobalt did not change hepatic ET-1 gene expression. The abundance of ET-3 mRNA in the livers of normoxic animals was about 6% of that found in the kidneys. The expression of the ET-3 gene in the livers was decreased by CO, but was not changed by any of the other experimental conditions used. These fi...Continue Reading
References
Oct 29, 1992·Nature·D ShweikiE Keshet
Aug 1, 1992·The American Journal of Physiology·H ScholzC Bauer
Sep 1, 1992·The Journal of Clinical Investigation·J D Firth, P J Ratcliffe
Mar 1, 1992·The Journal of Clinical Investigation·K U EckardtA Kurtz
Mar 16, 1992·Biochimica Et Biophysica Acta·J L WiebkeW B Guggino
Apr 1, 1992·Physiological Reviews·W Jelkmann
Sep 3, 1991·Klinische Wochenschrift·M Le HirA Kurtz
Sep 1, 1991·The Journal of Clinical Investigation·S KourembanasD V Faller
Oct 1, 1991·The Journal of Investigative Dermatology·V FalangaM B Sporn
Aug 1, 1990·The Journal of Experimental Medicine·P J RatcliffeJ I Bell
Aug 1, 1990·The Journal of Clinical Investigation·S KourembanasD V Faller
Mar 31, 1988·Nature·M YanagisawaT Masaki
Jun 15, 1989·Biochemical Pharmacology·M Yanagisawa, T Masaki
Feb 1, 1989·The Journal of Clinical Investigation·M S SimonsonM J Dunn
Sep 1, 1989·Nihon rinsho. Japanese journal of clinical medicine·T IshikawaT Masaki
Jan 1, 1989·The Journal of Clinical Investigation·W L MillerJ C Burnett
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M W MacCumberS H Snyder
Aug 1, 1989·Atherosclerosis·Y HirataF Marumo
Dec 9, 1988·Science·M A GoldbergH F Bunn
Jul 1, 1986·Molecular and Cellular Biology·N BeruE Goldwasser
Sep 1, 1994·The American Journal of Physiology·J AndoA Kamiya
May 1, 1994·Journal of the American Society of Nephrology : JASN·A NirJ C Burnett
Aug 15, 1994·Biochemical and Biophysical Research Communications·H KagamuY Mitsui
Jun 1, 1993·Pflügers Archiv : European journal of physiology·K U EckardtA Kurtz
Mar 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S BachmannK U Eckardt
Mar 1, 1993·British Journal of Pharmacology·J P CristolJ R Vane
Citations
Aug 10, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·A GrenzC H Gleiter
May 9, 1998·Respiration Physiology·M PfeiferA Kurtz
Nov 24, 1999·Pharmacology & Toxicology·J P LoennechenO Ellingsen
Feb 22, 2014·International Journal of Molecular Sciences·Richard SchäferLusine Danielyan
Apr 25, 2003·Canadian Journal of Physiology and Pharmacology·Xiaohong Tracey GanMorris Karmazyn
Feb 1, 1997·Kidney International·B K KrämerA Kurtz
Jan 17, 2002·The Urologic Clinics of North America·L Lerman, S C Textor
Sep 15, 1998·The Journal of Laboratory and Clinical Medicine·S CastellaniG Masotti
Dec 13, 2005·American Heart Journal·Sonia RalliGregg C Fonarow
Jun 26, 2001·Microvascular Research·D UhlmannH U Spiegel
Dec 23, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F SchwedaB K Krämer
Nov 24, 1999·Hypertension·S CastellaniG Masotti
Aug 24, 2001·Pediatric Research·T PerreaultJ Baribeau
Sep 4, 1999·Endothelium : Journal of Endothelial Cell Research·A G MinchenkoA M Lefer
Jun 20, 2014·PloS One·Pushpankur GhoshalTohru Ikuta
Oct 24, 2002·Blood·Neil M MatsuiStephen H Embury
Oct 8, 1999·Journal of Cardiovascular Pharmacology·E B FriedrichD Elsner
Jun 6, 2003·American Journal of Physiology. Renal Physiology·Richard Debigaré, S Russ Price
Jul 4, 2003·Canadian Journal of Physiology and Pharmacology·Thérèse Perreault, Flavio Coceani
Feb 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·F C BlumbergM Pfeifer
Oct 23, 2002·Journal of Applied Physiology·Friedrich C BlumbergMichael Pfeifer
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A LuchnerJ C Burnett
Feb 13, 2010·European Journal of Medical Research·S W ReinholdB K Krämer
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·B H PannenK K Geiger
Jul 15, 1999·Journal of the American Society of Nephrology : JASN·L O LermanJ C Romero