Influence of ibuprofen on phospholipid membranes

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Sebastian JakschBert Nickel

Abstract

A basic understanding of biological membranes is of paramount importance as these membranes comprise the very building blocks of life itself. Cells depend in their function on a range of properties of the membrane, which are important for the stability and function of the cell, information and nutrient transport, waste disposal, and finally the admission of drugs into the cell and also the deflection of bacteria and viruses. We have investigated the influence of ibuprofen on the structure and dynamics of L-α-phosphatidylcholine (SoyPC) membranes by means of grazing incidence small-angle neutron scattering, neutron reflectometry, and grazing incidence neutron spin echo spectroscopy. From the results of these experiments, we were able to determine that ibuprofen induces a two-step structuring behavior in the SoyPC films, where the structure evolves from the purely lamellar phase for pure SoyPC over a superposition of two hexagonal phases to a purely hexagonal phase at high concentrations. A relaxation, which is visible when no ibuprofen is present in the membrane, vanishes upon addition of ibuprofen. This we attribute to a stiffening of the membrane. This behavior may be instrumental in explaining the toxic behavior of ibuprofen ...Continue Reading

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Citations

Jul 4, 2018·Small·Lin SongPeter Müller-Buschbaum
Jul 2, 2017·Scientific Reports·Sebastian JakschHenrich Frielinghaus
Nov 29, 2017·Physical Chemistry Chemical Physics : PCCP·G MangiapiaH Frielinghaus
Jun 14, 2018·Journal of Applied Crystallography·Stefan MattauchThomas Bruckel
Oct 2, 2020·Biomolecules·Jan KremkowHolger A Scheidt
Jun 6, 2017·Chemistry and Physics of Lipids·Lisa LautnerTobias Unruh
Apr 8, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Megan WoodSunghee Lee
Jul 9, 2021·Soft Matter·Sudipta Gupta, Rana Ashkar
Aug 28, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Simou SunPaul S Cremer
Aug 14, 2018·Molecular Pharmaceutics·Ramsia SreijThomas Hellweg
Sep 6, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Alexandros KoutsioubasDidier Lairez
Aug 10, 2019·ACS Applied Materials & Interfaces·Lin SongPeter Müller-Buschbaum

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