Influence of IL-6, IL-10, IFN-γ and TNF-α genetic variants on susceptibility to diabetic kidney disease in type 2 diabetes mellitus patients

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Shadia A FathyAbdulnabi T Alattar

Abstract

Data from previous studies on the role of inflammatory cytokines as biomarkers for diabetic kidney disease (DKD) are contradictory. The association of a particular inflammatory cytokine single nucleotide polymorphism (SNP) with susceptibility to DKD has not been consistently replicated. We aimed to investigate the utility of inflammatory cytokines as biomarkers for DKD in type 2 diabetes mellitus (T2DM) patients. Association of inflammatory cytokine gene SNPs with the development of DKD was also explored. One hundred and fifty-nine Kuwaiti subjects were recruited in this study, including 50 T2DM patients without DKD, 67 diabetic DKD patients and 42 healthy subjects. Plasma levels of interleukin-6 (IL-6), IL-10, interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) were measured by enzyme-linked immunosorbent assays. Nine SNPs, including 2 SNPs in IL-6, 3 SNPs in IL-10, 1 SNP in IFN-γ and 3 SNPs in TNF-α, were genotyped using TaqMan SNP genotyping assays. Diabetic DKD patients showed higher IL-6, IL-10, IFN-γ and TNF-α levels than those without DKD. Diabetic DKD patients had a significantly higher frequency of IL-10 - 1082 A allele than those without DKD (p = 0.001). No significant association of IL-6 - 174/-597 haplo...Continue Reading

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Citations

Aug 21, 2020·Critical Reviews in Food Science and Nutrition·Jing YangJiajia Song
Jul 30, 2020·BMC Nephrology·Liliane Silvano AraújoJuliana Reis Machado
May 6, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Mengwei LiuWanyang Liu
Mar 9, 2021·Journal of Diabetes and Its Complications·Jaya Prakash Nath AmbinathanDavid Z I Cherney
Apr 24, 2021·Nature Communications·Swayam Prakash SrivastavaJulie Goodwin

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