Influence of immune status on virus-derived transplantable hepatoma in chickens

Journal of Toxicology and Environmental Health
I Földes

Abstract

The transplantable MC-29 virus-derived hepatoma is a suitable model for studying the influence of immune status on virus-derived hepatomas in chickens. It was found that both humoral and cellular immunologic reactions have a role in the pathogenesis of virus-derived hepatomas and that virus-derived hepatomas can be influenced by nonspecific immunostimulation. The lymphoid system was profoundly altered in hepatoma-bearing chickens; this cannot be neglected when studying correlations between immune reactions and carcinogenesis. Profound changes were also observed in protein synthesis and the steroid receptor system of hepatoma-bearing chickens compared to healthy birds; this also complicates the understanding of the role of immune mechanisms in carcinogenesis.

Related Concepts

Pathogenic Aspects
Pathogenesis
Liver Carcinoma
Increased Immunologic Activity [PE]
Tyrosine Aminotransferase
Hepatoma, Novikoff
Rous-Associated Virus
Protein Biosynthesis
BCG Vaccine
Receptors, Steroid

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