Influence of immunotherapy with interferon-alpha on regulatory T cells in renal cell carcinoma patients

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Katsunori TatsugamiSeiji Naito

Abstract

Interferon-alpha (IFN-alpha) has extremely broad effects on the immune system, and the influence of IFN-alpha on regulatory T (Treg) cells is not fully known. In this report, Treg cells were analyzed in patients with metastatic renal cell carcinoma (RCC) following IFN-alpha monotherapy or treatment with IFN-alpha and interleukin (IL)-2. CD4(+) and FoxP3(+) Treg cells were significantly decreased for 2 weeks after the initiation of IFN-alpha monotherapy, but recovered later as treatment proceeded. Patients treated with both IFN-alpha and IL-2 increased their Treg cell levels during the first 2 weeks after initiation of treatment. Patients who derived complete response (CR), partial response (PR), or stable disease (SD) from IFN-alpha monotherapy had lower Treg cell levels before treatment than did patients whose disease progressed. Low Treg cell levels before treatment may therefore be advantageous to subsequent immunotherapy with IFN-alpha, and predictive for treatment results in RCC patients.

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Citations

Oct 12, 2012·Cancer Immunology, Immunotherapy : CII·Ario TakeuchiSeiji Naito
Sep 13, 2011·Medicinski pregled·Ivan LevakovOlivera Vignjević
Mar 13, 2014·International Journal of Molecular Sciences·Svetlana KarakhanovaAlexandr V Bazhin
Jan 22, 2011·Clinical & Developmental Immunology·Momoe Itsumi, Katsunori Tatsugami
May 24, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Hirokazu MatsushitaYoshihiro Wada
May 27, 2014·American Society of Clinical Oncology Educational Book·Manuela Schmidinger

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

FlowJo

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