PMID: 9418975Jan 7, 1998Paper

Influence of IN-1 antibody and acidic FGF-fibrin glue on the response of injured corticospinal tract axons to human Schwann cell grafts

Journal of Neuroscience Research
J D GuestR P Bunge

Abstract

Two strategies have been shown by others to improve CST regeneration following thoracic spinal cord injury: 1) the administration of a monoclonal antibody, IN-1, raised against a myelin-associated, neurite growth inhibitory protein, and 2) the delivery of acidic fibroblast growth factor (aFGF) in fibrin glue in association with peripheral nerve grafts. Because autologous transplantation of human Schwann cells (SCs) is a potential strategy for CNS repair, we evaluated the ability of these two molecular agents to induce CST regeneration into human SC grafts placed to span a midthoracic spinal cord transection in the adult nude rat, a xenograft tolerant strain. IN-1 or control (HRP) antibodies were delivered to the injury/graft region by encapsulated hybridoma cells ("IN-1 ravioli") or daily infusion of hybridoma culture supernatant; aFGF-fibrin glue was placed in the same region in other animals. Anterograde tracing from the motor cortex using the dextran amine tracers, Fluororuby (FR) and biotinylated dextran amine (BDA), was performed. Thirty-five days after grafting, the CST response was evaluated qualitatively by looking for regenerated CST fibers in or beyond grafts and quantitatively by constructing camera lucida composites...Continue Reading

References

Sep 1, 1978·Human Pathology·R BronsonE T Hedley-Whyte
Jul 1, 1992·The International Journal of Neuroscience·Q P MaJ S Han
May 1, 1992·The Journal of Clinical Investigation·G StrassmannC O Jacob
Jan 1, 1991·Experimental Brain Research·M M GiacobiniL Olson
Jan 1, 1991·Annals of the New York Academy of Sciences·K A ThomasJ Menke
Jun 1, 1989·Plastic and Reconstructive Surgery·P G CordeiroR Madison
Mar 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·T YamamotoT Imai
May 1, 1987·The Histochemical Journal·C J JonesR W Stoddart
May 1, 1967·The Journal of Physiology·M E Holman, A McLean
Sep 1, 1984·Neurology·P S Fishman, J P Kelley
Dec 20, 1983·The Journal of Comparative Neurology·D R Bernstein, D J Stelzner
Mar 20, 1980·Nature·P M RichardsonA J Aguayo
Dec 1, 1993·Developmental Biology·S MeinersH M Geller
Aug 1, 1995·Journal of Neuroscience Research·B T ZhangT Takenaka
Mar 1, 1995·Journal of Neuroscience Research·F ZhangW G Tatton
Mar 1, 1993·Experimental Neurology·M KoshinagaS R Whittemore
Jan 1, 1995·Journal of Neuroscience Research·I R Boniece, J A Wagner
Feb 15, 1995·Journal of Neuroscience Research·Y J HouV K Menon
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·T K MorrisseyR P Bunge
Jan 1, 1994·Progress in Brain Research·W TetzlaffA M Bedard

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Citations

Jan 10, 2013·World Neurosurgery·Nicole Forgione, Michael G Fehlings
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·L I BenowitzN Irwin
May 25, 1999·Journal of Anatomy·J P Fraher
Jul 2, 2002·Journal of Anatomy·John Fraher
May 16, 2007·Journal of Neuroengineering and Rehabilitation·Ali Samadikuchaksaraei
Feb 12, 2010·Journal of Neurotrauma·Wolfram TetzlaffBrian K Kwon
Nov 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takuji KurimotoLarry I Benowitz
Oct 18, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael G Fehlings, Reaz Vawda
Feb 3, 1999·Annals of the New York Academy of Sciences·J D Steeves, W Tetzlaff
Nov 4, 2005·Journal of Neurosurgery. Spine·Jorge E Collazos-CastroManuel Nieto-Sampedro
Jun 15, 2011·Journal of Neurosurgery. Spine·Jau-Ching WuHenrich Cheng
Sep 10, 2003·Journal of Neurosurgery·Rajiv MidhaMolly S Shoichet
Jan 8, 2004·The Journal of Investigative Dermatology·David J Geer, Stelios T Andreadis
Apr 10, 2004·Neurological Research·Jason S BelkasRajiv Midha
Nov 9, 2016·Neuroscience Letters·Caitlin E Hill
Feb 23, 2017·Journal of Neurotrauma·Kim D AndersonAllan D Levi
Oct 25, 2013·Cell Transplantation·Ryan R WilliamsMary Bartlett Bunge
Mar 14, 2002·Microsurgery·Yun-An TsaiHenrich Cheng
Jul 22, 2006·Nature Reviews. Neuroscience·Sandrine ThuretFred H Gage
Mar 9, 2011·Journal of Neurotrauma·Michael G FehlingsLisa McKerracher
Sep 12, 2000·Neurosurgery·K Barami, F G Diaz
Apr 14, 2000·Neurosurgery·N Theodore, V K Sonntag

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