Influence of inflammation on voriconazole metabolism

Antimicrobial Agents and Chemotherapy
M A Encalada VenturaJ-W C Alffenaar

Abstract

Voriconazole pharmacokinetics shows a large inter- and intrapatient variability. Inflammation is associated with changes in the expression of CYP isoenzymes. Here, we evaluated the influence of inflammation, marked by C-reactive protein (CRP) levels in blood, on the metabolism of voriconazole. Observational data showed an association between CRP level and the ratio of voriconazole N-oxide to voriconazole.

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Citations

Jul 20, 2016·The Journal of Antimicrobial Chemotherapy·Anette VeringaJan-Willem C Alffenaar
Sep 8, 2016·The Journal of Antimicrobial Chemotherapy·Anette VeringaJan-Willem C Alffenaar
Feb 18, 2016·Antimicrobial Agents and Chemotherapy·M A Encalada VenturaJ W C Alffenaar
Jun 20, 2019·Drug Metabolism Reviews·Josefine SchulzCharlotte Kloft
May 18, 2019·Clinical Pharmacology and Therapeutics·Sophie GravelVeronique Michaud
May 11, 2018·British Journal of Clinical Pharmacology·Bas VreugdenhilRoger J M Brüggemann
Jan 29, 2019·Clinical Pharmacokinetics·Changcheng ShiNengming Lin
Nov 20, 2016·British Journal of Clinical Pharmacology·Mendy Ter AvestJan-Willem C Alffenaar
Sep 30, 2020·Antimicrobial Agents and Chemotherapy·Takuto TakahashiMark N Kirstein
Jul 14, 2020·Pharmacology & Therapeutics·Françoise Stanke-LabesqueUNKNOWN French Society of Pharmacology and Therapeutics
Nov 2, 2020·Thérapie·Anaëlle ChavantFrançoise Stanke-Labesque
Sep 1, 2021·Clinical Pharmacokinetics·Camille LenoirCaroline F Samer
Oct 1, 2021·The Annals of Pharmacotherapy·C Michael White

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