Influence of inflammatory disorders and infection on iron absorption and efficacy of iron-fortified foods

Nestlé Nutrition Institute Workshop Series
Richard Hurrell

Abstract

The provision of iron- fortified foods is a common strategy to prevent iron deficiency; however, ensuring adequate iron absorption is a challenge. Iron bioavailability depends on the choice of iron compound, the presence enhancers and inhibitors of absorption in the food matrix, and the physiological state of the consumer, including iron status, other nutritional deficiencies and inflammatory disorders. Inflammation associated with infections and inflammatory disorders would be expected to decrease iron absorption and reduce the efficacy of iron- fortified foods. The decreased absorption is due to an increase in circulating hepcidin in response to inflammatory cytokines. Hepcidin degrades ferroportin and blocks the passage of iron from the intestinal cell to the plasma. This is the innate immune response to infections and aims to restrict pathogen growth by restricting iron supply. Stable isotope studies have reported women and children with chronic malaria parasitemia or febrile malaria to have increased inflammatory cytokines, increased hepcidin and much decreased iron absorption. No studies have specifically investigated the efficacy of iron- fortified foods in the absence and presence of infections. In contrast, inflammatio...Continue Reading

Citations

Oct 20, 2017·Maternal & Child Nutrition·Calistus WilundaKoji Kawakami
Mar 15, 2020·Canadian Journal of Public Health = Revue Canadienne De Santé Publique·Emad TahirMélanie Lemire
Jan 12, 2021·Saudi Journal of Biological Sciences·Ali A AlageeliFarjah H Algahtani
May 7, 2021·Journal of Nutrition and Metabolism·Orapa SuteerojntrakoolMary Fewtrell
Sep 27, 2021·The Cochrane Database of Systematic Reviews·Katharina da Silva LopesErika Ota

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition
Richard Hurrell
International Journal of Obesity : Journal of the International Association for the Study of Obesity
M B ZimmermannRichard Hurrell
© 2021 Meta ULC. All rights reserved