Influence of inhibitors of prostaglandin synthesis on the canine pulmonary vascular bed.

The American Journal of Physiology
P J KadowitzA L Hyman

Abstract

The effects of two chemically dissimilar inhibitors of prostaglandin (PG) synthesis on vascular resistance and responses to pressor and depressor hormones were evaluated in the canine pulmonary vascular bed. Indomethacin or meclofenamate, 2.5-5 mg/kg iv, increased lobar arterial pressure. Since lobar blood flow was held constant and left atrial pressure did not change, the rise in pressure reflects an increase in vascular resistance. The rise in lobar pressure after indomethacin occurred in the absence of a change in lobar venous or translobar airway pressure. This agent enhanced the response to angiotensin but not to norepinephrine. Meclofenamate decreased responses to both agents. Indomethacin enhanced the dilator response to PGE1 and both indomethacin and meclofenamate increased the response to PGF2alpha. These data indicate that the rise in resistance after indomethacin or meclofenamate was the result of vasoconstriction in vessels upstream to the small veins, presumed to be small arteries. These data are consistent with the hypothesis that under resting conditions synthesis of a dilator prostaglandin may be important for the maintenance of the pulmonary vascular bed in a dilated state. However, results of the present study...Continue Reading

Citations

Nov 1, 1984·Clinical and Experimental Pharmacology & Physiology·A D Siefkin, G H Parsons
Nov 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Syed R BaberPhilip J Kadowitz
Feb 1, 1978·Acta Physiologica Scandinavica·T WibergK M Gautvik
Jun 10, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Justin A EdwardPhilip J Kadowitz
Sep 1, 1979·Circulation Research·A L Hyman, P J Kadowitz
Apr 1, 1980·Environmental Health Perspectives·P J KadowitzA L Hyman
Apr 1, 1977·Respiration Physiology·C A HalesH Kazemi

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