PMID: 6983886Aug 1, 1982Paper

Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas

British Journal of Cancer
P J Tutton, D H Barkla

Abstract

Previous studies have shown that in certain tissues, including colonic carcinomas, cell proliferation may be promoted by serotonin, and indirect evidence suggests that the effects of this amine on colonic tumours involves a cellular-uptake mechanism. In the present study, two specific inhibitors of serotonin uptake, Citalopram and Fluoxetine, are examined for their effects on cell proliferation and tumour growth. Each of the agents was found to suppress cell division in dimethylhydrazine-induced colonic tumours in rats, and to retard the growth of 2 out of 3 lines of human colonic tumours propagated as xenografts in immune-deprived mice.

Citations

Jun 1, 1996·Molecular Carcinogenesis·F S LaBella, L J Brandes
Oct 6, 2000·Epidemiology·S O DaltonJ H Olsen
Oct 27, 2015·Medicine·Hsiang-Lin ChanVincent Chin-Hung Chen
Feb 14, 2006·BJU International·Emad J SiddiquiCecil S Thompson
Feb 1, 2019·Psycho-oncology·Gaia PocobelliJessica Chubak
Aug 2, 2019·World Journal of Clinical Cases·Yang-Zi DiQiang Tang
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P J Tutton, D H Barkla
Jun 1, 1995·Journal of Clinical Psychopharmacology·L G Miller
Feb 1, 1995·Journal of Clinical Psychopharmacology·L J Brandes, M Cheang
Jun 1, 1996·Clinical and Experimental Pharmacology & Physiology·P F SheehanD H Barkla
Mar 1, 1984·Klinische Wochenschrift·R OsiekaC G Schmidt
Mar 17, 2010·International Journal of Cancer. Journal International Du Cancer·Jessica ChubakMargaret T Mandelson
Jan 13, 2005·Canadian Journal of Physiology and Pharmacology·Fátima MartelM A Vieira-Coelho
Sep 30, 2010·British Journal of Cancer·D P Cronin-FentonH T Sørensen
Aug 24, 2013·Experimental Biology and Medicine·Anna M Bielecka, Ewa Obuchowicz
Jun 28, 2012·European Journal of Gastroenterology & Hepatology·Hyun-Ki LeeSang Min Park
Apr 29, 2016·Oncotarget·Desiré K ChristensenSusan K Lutgendorf
Nov 27, 2004·Cell Biochemistry and Function·Chung-Tai Yue, Yu-Li Liu
Aug 31, 2004·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Ronald N HinesPaige L Williams
May 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Justin StebbingMark Bower
Jul 23, 2009·Pharmacoepidemiology and Drug Safety·Patricia F CooganLynn Rosenberg
Oct 22, 2003·Journal of Experimental Therapeutics & Oncology·Donna A VolpePatrick J Faustino
May 24, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jenna F Kiridly-CalderbankKatherine W Reeves
Jan 8, 2021·Parasites & Vectors·Michaela Herz, Klaus Brehm
Feb 4, 2010·Journal of Proteome Research·Yunping QiuWei Jia

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