Influence of inhibitory synaptic kinetics on the interaural time difference sensitivity in a linear model of binaural coincidence detection

The Journal of the Acoustical Society of America
Christian Leibold

Abstract

Temporal correlations between the sound waves arriving at the two ears are used to extract the azimuthal position of sound sources. Nerve cells in the mammalian medial superior olive (MSO) that extract these binaural correlations are sensitive to interaural time differences (ITDs) in the range of about 10 micros. These neurons receive inputs from the two ears via four pathways, two excitatory and two inhibitory ones. In this paper, a simple linear model is fitted to the frequency dependence of ITD sensitivity of MSO neurons, which is quantified by the two parameters, characteristic phase and characteristic delay. The fit parameters are the relative delays and the relative strengths of the two inhibitory pathways and thus specify the underlying ITD-detecting circuit assuming a non-Jeffress-like situation, i.e., no excitatory delay lines but phase-locked inhibition. The fitting procedure finds the parameters of these inhibitory pathways such that they account for a desired frequency dependence of ITD sensitivity. It is found that positive characteristic delays require a finite amount of ipsilateral inhibition that arrives at roughly the same time as ipsilateral excitation as well as contralateral inhibition that lags contralatera...Continue Reading

References

Aug 15, 1991·The Journal of Comparative Neurology·K K GlendenningR J Wenthold
Aug 1, 1990·Journal of Neurophysiology·T C Yin, J C Chan
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·R KempterJ L van Hemmen
Mar 29, 2001·Nature Neuroscience·D McAlpineA R Palmer
Apr 13, 2002·Hearing Research·Malte KittelGeorg M Klump
Jun 13, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Christian LeiboldJ Leo van Hemmen
Jul 10, 2003·Trends in Neurosciences·David McAlpine, Benedikt Grothe
Dec 12, 2003·Biological cybernetics·Gytis SvirskisJohn Rinzel
Jul 13, 2004·The European Journal of Neuroscience·Ursula KochBenedikt Grothe
Aug 6, 2004·Nature·Nicol S Harper, David McAlpine
Mar 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yi ZhouH Steven Colburn
May 21, 2005·Physical Review Letters·Christian Leibold, J Leo van Hemmen
Aug 13, 2005·The Journal of Physiology·Anna K MagnussonUrsula Koch
Sep 2, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luisa L ScottNace L Golding
Nov 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel J Tollin, Tom C T Yin
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Philip X JorisMarcel van der Heijden
Dec 1, 2006·Nature·Hiroshi KubaHarunori Ohmori
Dec 26, 2006·Trends in Neurosciences·Philip Joris, Tom C T Yin
Jul 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael PeckaBenedikt Grothe
Feb 1, 1948·Journal of Comparative and Physiological Psychology·L A JEFFRESS

❮ Previous
Next ❯

Citations

Mar 30, 2011·PLoS Computational Biology·Hannes LülingChristian Leibold
Apr 15, 2014·Trends in Neurosciences·Katrin Vonderschen, Hermann Wagner
May 9, 2014·Nature Communications·Michael H MyogaBenedikt Grothe
Oct 4, 2014·Journal of Computational Neuroscience·Jessica LehmannHartmut Führ
Jun 8, 2011·Current Opinion in Neurobiology·Go Ashida, Catherine E Carr
Oct 18, 2014·Frontiers in Neural Circuits·Benedikt Grothe, Michael Pecka
Jul 22, 2011·Journal of Neurophysiology·Mitchell L Day, Malcolm N Semple
Mar 25, 2016·Journal of Neurophysiology·Andrius PlauškaMarcel van der Heijden

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.