PMID: 8604554Nov 1, 1995Paper

Influence of inoculation route on the carrier state of Salmonella choleraesuis in swine

Veterinary Microbiology
J T GrayM R Ackermann

Abstract

This study was designed to investigate the carrier state of swine infected with Salmonella choleraesuis. Thirty-five pigs were divided into 3 groups. Groups 1 (n = 15) and 2 (n = 16) were challenged with 10(8) CFU of S. choleraesuis intranasally or by gastric route, respectively. Group 3 (n = 4) served as uninoculated controls. Pigs were necropsied at 2, 4, 6, and 12 weeks post inoculation. Clinical signs and microscopic lesions were more severe for group 1. Salmonella choleraesuis was recovered from a greater percentage of tissue samples for group 1 versus group 2 at 2, 4, and 6 weeks post inoculation. No differences were observed between groups at 12 weeks post inoculation. Regardless of route of inoculation, S. choleraesuis was most often recovered from the ileocolic junction, ileocolic lymph node, cecal contents, tonsil, lung and colon. Both groups shed S. choleraesuis in the feces sporadically throughout the 12 week period indicating that a carrier state is maintained for at least 12 weeks. However, group 1 shed higher numbers of S. choleraesuis initially. Serum IgG, IgM, and IgA antibody responses to S. choleraesuis lipopolysaccharide and heat extract antigens were observed for both groups. Higher serum IgG antibody titer...Continue Reading

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Citations

Jul 18, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Shu-Hong ZhaoChristopher K Tuggle
Jul 20, 2002·Veterinary Immunology and Immunopathology·P M van DiemenT S Wallis
May 4, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Scott A McEwen, Paula J Fedorka-Cray
Jul 5, 2005·Foodborne Pathogens and Disease·Peter R DaviesFrank T Jones
Feb 5, 2008·Applied and Environmental Microbiology·Douglas M HeithoffMichael J Mahan
Nov 1, 2011·Applied and Environmental Microbiology·Ursula RajtakSéamus Fanning
Apr 16, 2004·Clinical Microbiology Reviews·Cheng-Hsun ChiuChishih Chu
Sep 14, 2007·BMC Microbiology·Wendy RodenburgIngeborg M J Bovee-Oudenhoven
Apr 19, 2012·PLoS Pathogens·Douglas M HeithoffMichael J Mahan
Nov 8, 2001·Journal of the American Veterinary Medical Association·H F TrouttA Hogue
Feb 9, 2016·Zoonoses and Public Health·A D Wales, R H Davies
Dec 21, 2005·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·M Vieira-PintoC Martins
Sep 3, 2003·The Journal of Veterinary Medical Science·Takayuki OsumiKoshi Yamamoto
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Aug 27, 2015·Journal of Animal Science and Biotechnology·Xiaoyu LiYongping Xu
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