Influence of insulin on the healing of exposed dental pulp after pulp capping: An experimental study in a dog model

Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
Mokhtar A Al-AnesiEhab S Abd-Elhamid

Abstract

This study investigates the influence of insulin on pulp tissue healing after pulp capping in diabetic dogs. Diabetes mellitus was induced in four dogs, and their blood glucose levels were adjusted by insulin to normoglycemic level in two dogs (normoglycemic group) and to hyperglycemic level in two dogs (hyperglycemic group). Class V buccal cavities were performed in 15 teeth in each diabetic dog and two normal dogs (control group). The three groups (30 teeth each) were divided according to the capping materials into three subgroups (10 teeth each) including: subgroup A - mineral trioxide aggregate (MTA), subgroup B - bioaggregate (BA), and subgroup C - calcium hydroxide (Ca(OH)2 ). Each subgroup was divided into two subdivisions according to the evaluation period, subdivision 1: 1 month and subdivision 2: 2 months. Qualitative and quantitative evaluations of the inflammation and dentine bridge formation were assessed histologically. The hyperglycemic diabetic group exhibited significant higher inflammatory cell count and scores and lower dentine bridge thickness than those of the normoglycemic diabetic and control groups (P < .05). There were no significant differences in these parameters between the normoglycemic diabetic and...Continue Reading

References

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Dec 4, 2003·Journal of Endodontics·Antonio ScaranoAdriano Piattelli
Dec 25, 2007·Journal of Endodontics·Maria de Lourdes R AccorinteLoguercio Dourado Alessandro
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Dec 18, 2016·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ahmed M NegmMohamed M Nagy
May 25, 2021·The Saudi Dental Journal·Inas M Al-SherbinyHagar A Bastawy

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Citations

Jan 7, 2021·International Journal of Experimental Pathology·Ebtesam O Abo El-MalSalma H El Ashry

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