Influence of integrated molecular pathology test results on real-world management decisions for patients with pancreatic cysts: analysis of data from a national registry cohort

Diagnostic Pathology
David LorenNadim Haddad

Abstract

Integrated molecular pathology (IMP) approaches based on DNA mutational profiling accurately determine pancreatic cyst malignancy risk in patients lacking definitive diagnoses following endoscopic ultrasound imaging with fine-needle aspiration of fluid for cytology. In such cases, IMP 'low-risk' and 'high-risk' diagnoses reliably predict benign and malignant disease, respectively, and provide improved risk stratification for malignancy than a model of the 2012 International Consensus Guideline (ICG) recommendations. Our objective was to determine if initial adjunctive IMP testing influenced future real-world pancreatic cyst management decisions for intervention or surveillance relative to ICG recommendations, and if this benefitted patient outcomes. Analysis of data from the previously described National Pancreatic Cyst Registry. Associations between real-world decisions (intervention vs. surveillance), ICG model recommendations (surgery vs. surveillance) and IMP diagnoses (high-risk vs. low-risk) were evaluated using 2 × 2 tables. Kaplan Meier and hazard ratio analyses were used to assess time to malignancy. Odds ratios (OR) for surgery decision were determined using logistic regression. Of 491 patients, 206 received clinical ...Continue Reading

References

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Jun 2, 2015·Gastroenterology·Mohammad A Al-Haddad, Thomas Kowalski

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Citations

Aug 30, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Divyanshoo R KohliRavi Vachhani
Oct 9, 2018·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Rachel E SimpsonC M Schmidt

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Methods Mentioned

BETA
surgical resection

Software Mentioned

IMP

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