Influence of intensity of food restriction on skeletal muscle mitochondrial energy metabolism in rats

American Journal of Physiology. Endocrinology and Metabolism
Gyasi JohnsonPatrick Ritz

Abstract

Variable durations of food restriction (FR; lasting weeks to years) and variable FR intensities are applied to animals in life span-prolonging studies. A reduction in mitochondrial proton leak is suggested as a putative mechanism linking such diet interventions and aging retardation. Early mechanisms of mitochondrial metabolic adaptation induced by FR remain unclear. We investigated the influence of different degrees of FR over 3 days on mitochondrial proton leak and mitochondrial energy metabolism in rat hindlimb skeletal muscle. Animals underwent 25, 50, and 75% and total FR compared with control rats. Proton leak kinetics and mitochondrial functions were investigated in two mitochondrial subpopulations, intermyofibrillar (IMF) and subsarcolemmal (SSM) mitochondria. Regardless of the degree of restriction, skeletal muscle mass was not affected by 3 days of FR. Mitochondrial basal proton conductance was significantly decreased in 50% restricted rats in both mitochondrial subpopulations (46 and 40% for IMF and SSM, respectively) but was unaffected in other groups compared with controls. State 3 and uncoupled state 3 respiration rates were decreased in SSM mitochondria only for 50% restricted rats when pyruvate + malate was used...Continue Reading

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Citations

Jun 24, 2011·Journal of Physiology and Biochemistry·Lisa RodriguesRaquel Seiça
Apr 17, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yana ChenJon J Ramsey
Apr 25, 2012·PloS One·Dominique-Marie VotionDidier Serteyn
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Jun 17, 2009·Biophysical Journal·Aurora Muñoz-LosaBenedetta Mennucci
Jan 24, 2018·The Journal of Experimental Biology·Damien RousselCaroline Romestaing

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