Influence of interactions between genes and childhood trauma on refractoriness in psychiatric disorders

Progress in Neuro-psychopharmacology & Biological Psychiatry
Ji Sun Kim, Seung-Hwan Lee

Abstract

Psychiatric disorders are excellent disease models in which gene-environmental interaction play a significant role in the pathogenesis. Childhood trauma has been known as a significant environmental factor in the progress of, and prognosis for psychiatric illness. Patients with refractory illness usually have more severe symptoms, greater disability, lower quality of life and are at greater risk of suicide than other psychiatric patients. Our literature review uncovered some important clinical factors which modulate response to treatment in psychiatric patients who have experienced childhood trauma. Childhood trauma seems to be a critical determinant of treatment refractoriness in psychotic disorder, bipolar disorder, major depressive disorder, and post-traumatic stress disorder. In patients with psychotic disorders, the relationship between childhood trauma and treatment-refractoriness appears to be mediated by cognitive impairment. In the case of bipolar disorder, the relationship appears to be mediated by greater affective disturbance and earlier onset, while in major depressive disorder the mediating factors are persistent, severe symptoms and frequent recurrence. In suicidal individuals, childhood maltreatment was associat...Continue Reading

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Citations

May 30, 2016·Schizophrenia Research·Ahmed N HassanVincenzo De Luca
Jun 28, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yong-Ku Kim
Dec 14, 2018·Pharmacological Reports : PR·Paulina Jaworska-Andryszewska, Janusz K Rybakowski
Jan 7, 2020·Acta Neuropsychiatrica·Caroline Normann, Henriette N Buttenschøn
Apr 12, 2019·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Federica SancassianiLiliana Dell'Osso
Oct 12, 2017·Frontiers in Psychology·Alicia Valiente-GómezBenedikt L Amann
Aug 21, 2019·Annals of General Psychiatry·Fiona DeviMythily Subramaniam
May 19, 2021·BMC Psychiatry·Anna B ChaplinGolam M Khandaker

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