Influence of interval between primary surgery and chemotherapy on short-term survival of patients with advanced ovarian, tubal or peritoneal cancer

Gynecologic Oncology
T PaulsenC Tropé

Abstract

To investigate the impact on short-term survival of time between surgery and start of first chemotherapy cycle in patients with advanced ovarian cancer. This prospective, population-based study comprised 371 patients with epithelial ovarian, tubal or peritoneal cancer diagnosed in 2002-2003. All patients underwent primary surgery, followed at different intervals by chemotherapy. The data were derived from notifications to the Norwegian Cancer Registry and included medical, surgical and histopathological records. Kaplan-Meier plots were used to show differences in survival, and Cox regression analysis was used to show the effect of prognostic factors on survival, expressed as hazard ratios (HRs). No difference in survival between patient groups was seen when time between surgery and start of chemotherapy was divided into quartiles. The group of patients with no residual disease and an interval between surgery and start of chemotherapy equal to or more than 6 weeks had non-significantly worse survival (unadjusted HR = 1.86; adjusted HR = 1.35) than those with an interval of less than 6 weeks. Patients with residual disease after surgery and chemotherapy at an interval of less than 6 weeks had worse short-term survival than patien...Continue Reading

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Citations

Oct 22, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K S TewariR A Burger
Dec 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Inger Kristin LarsenBjørn Møller
May 23, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·E ChéreauR Rouzier
Aug 28, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S MahnerA du Bois
Jan 28, 2014·PloS One·Sébastien BenzekryPhilip Hahnfeldt
Jan 24, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Pedro Luiz Serrano UsónAuro Del Giglio
May 3, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·N ColomboUNKNOWN ESMO–ESGO Ovarian Cancer Consensus Conference Working Group
Feb 1, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Pedro Luiz Serrano UsónAuro Del Giglio
May 3, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ColomboUNKNOWN ESMO-ESGO Ovarian Cancer Consensus Conference Working Group
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ColomboUNKNOWN ESMO-ESGO Ovarian Cancer Consensus Conference Working Group

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