PMID: 7336979Sep 1, 1981Paper

Influence of intoxication by anticholinesterase agents on core temperature in rats: relationships between hypothermia and acetylcholinesterase inhibition in different brain areas

Acta Pharmacologica Et Toxicologica
C Coudray-LucasJ Wepierre

Abstract

The early and late effect of three anticholinesterase agents (physostigmine, paraoxon and soman) on core temperature and brain acetylcholinesterase (AcChE) inhibition are compared. The study was performed in adult male rats using sublethal doses of all drugs. AcChE activity was determined by hypothalamus, striatum, hippocampus, medulla oblongata-pons and rest of the brain. The co-existence of intoxication symptoms, hypothermia and AcChE inhibitions was clearly shown by the early effects. However, no relationship was found between the degree of hypothermia and that of inhibition whatever brain area. In contrast, late AcChE inhibition was not accompanied by symptoms and lowering of core temperature. Several hypotheses have been suggested to explain this phenomenon: de novo synthesis of enzyme, decreased sensitivity of neurotransmitter or return to normal of brain acetylcholine level through a negative feed back at the presynaptic level. The present data suggest that this latter assumption is the most likely.

References

Oct 15, 1979·European Journal of Biochemistry·M SunT Chou
Dec 1, 1977·Toxicology and Applied Pharmacology·P J Kurtz
Apr 1, 1977·Biochemical Pharmacology·L WeckerW D Dettbarn
Oct 1, 1973·European Journal of Pharmacology·E Meeter
Aug 1, 1968·European Journal of Pharmacology·E Meeter, O L Wolthuis
Mar 1, 1969·Toxicology and Applied Pharmacology·R R Lauwerys, S D Murphy
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE

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Citations

Sep 1, 1985·Bulletin of Environmental Contamination and Toxicology·W E Montz, R L Kirkpatrick
Sep 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C Coudray-LucasJ Wepierre
Oct 1, 1982·Acta Pharmacologica Et Toxicologica·M Prioux-GuyonneauJ Wepierre
Jul 1, 1996·Reviews on Environmental Health·C J Gordon
Aug 1, 1984·Acta Pharmacologica Et Toxicologica·C Coudray-LucasJ Wepierre
Mar 1, 1983·Acta Pharmacologica Et Toxicologica·C Coudray-LucasJ Wepierre

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