Influence of intra-articular tranexamic acid on cost savings and early functional outcomes in total knee arthroplasty.

Revista española de cirugía ortopédica y traumatología
A C Urgel GranadosÁ Castro Sauras

Abstract

Total knee arthroplasty (TKA) is a frequent intervention that can associate significant blood loss. There are several methods to avoid transfusions. One of the most relevant is tranexamic acid (TXA). Our purpose is to analyse the efficacy in terms of blood savings, transfusion needs, functional results, and cost-effectiveness of intra-articular (IA) administration in TKA. We conducted a retrospective analysis of historical cohorts (75 patients each) between January 2015 and December 2016. We included 150 patients (59,3% women) with a mean age of 73,58 years. The intervention consisted of administering 2 g of IA TXA with a contact time of 30 min. Demographic data, preoperative haematological status, surgery data, estimated total blood loss (ETBL), need for transfusion, functional results, and cost analysis were collected. The level of statistical significance was p ≤ 0,05. The incidence of transfusion was 17,33% in the control group and 5,33% in the TXA group (p = 0,039), with a relative risk reduction of 78,3%. The TXA cohort showed a reduction in ETBL (p < 0,0005), units transfused (p = 0,019) and length of stay (p = 0,004). All early functional parameters also improved, including a 10° improvement in both flexion and extensio...Continue Reading

References

Nov 5, 2010·The Journal of Bone and Joint Surgery. American Volume·Jean WongFrances Chung
Mar 16, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Shuvendu Prosad RoyOnkar Nath Nagi
Feb 19, 2013·Revista española de anestesiología y reanimación·S R Leal-NovalA Puppo
Jul 28, 2013·The Journal of Arthroplasty·Blake P GilletteRafael J Sierra
Aug 3, 2013·The Journal of Arthroplasty·Andrew G GeorgiadisMichael W Laker
Sep 27, 2013·The Journal of Arthroplasty·George F ChimentoSheena Babin
Mar 19, 2014·The Journal of Arthroplasty·John R TuttleLee E Rubin
Nov 3, 2015·Chinese Medical Journal·Fu-Qiang GaoHong Zhang
Feb 13, 2016·The Journal of Arthroplasty·Laura Serrano MateoAlejandro Gonzalez Della Valle
Jul 28, 2016·BMC Musculoskeletal Disorders·P PinsornsakS Chumchuen
Apr 11, 2017·The Journal of Knee Surgery·Joseph T Moskal, Susan G Capps
Mar 3, 2018·Medicina clínica·Álvaro López-HualdaJavier Martínez-Martín
Mar 22, 2018·Arthroplasty Today·Matthew J GrossoJeffrey A Geller
Mar 24, 2018·Transfusion Medicine Reviews·Joshua MontroyRodney H Breau
Apr 28, 2018·The Journal of Arthroplasty·Yale A FillinghamCraig J Della Valle
Nov 20, 2019·The Orthopedic Clinics of North America·Stephen ChambersWilliam M Mihalko

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.