PMID: 6186137Feb 1, 1983Paper

Influence of intracoronary platelet aggregation on ventricular electrical properties during partial coronary artery stenosis

The American Journal of Cardiology
P R KoweyR I Handin

Abstract

Several clinical studies suggest that drugs which interfere with platelet function may protect persons at risk for sudden death. However, there is no direct evidence that intracoronary platelet aggregation produces cardiac arrhythmias. Induction of fixed partial coronary stenoses in dogs resulted in spontaneous cyclical reductions in coronary blood flow of 21 to 81% (p less than 0.01). These changes are known to be associated with the formation and distal embolization of platelet aggregates. These reductions in coronary blood flow were accompanied by significant decreases in the repetitive extrasystole (-40%) and ventricular fibrillation (-38%) thresholds. Prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet activation, in increasing doses of from 25 to 100 ng/kg/min caused a stepwise decrease in the frequency and magnitude of coronary blood flow fluctuations and restored the vulnerable period thresholds to control levels. Indomethacin (5 mg/kg), an inhibitor of cyclo-oxygenase activation and platelet thromboxane A2 production, produced similar results. The mechanism of coronary blood flow reduction appears to be mechanical blockade of the vessel lumen by platelet thrombi and production of myocardial ischemia. Th...Continue Reading

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Citations

Aug 19, 2003·Heart·G Heusch, R Schulz
Aug 18, 2006·Basic Research in Cardiology·Andreas SkyschallyG Heusch
Jan 1, 1984·Annals of the New York Academy of Sciences·R L Verrier, B Lown
May 1, 1995·Neuroscience and Behavioral Physiology·L S Ul'yaninskii
Oct 11, 2017·Journal of Cardiovascular Pharmacology·Tomiya YasumasuYutaka Otsuji
Mar 26, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Andreas SkyschallyG Heusch

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