Influence of intralesional surgery on treatment outcome of chondrosarcoma

Cancer
T OzakiW Winkelmann

Abstract

Intralesional (IL) surgery for chondrosarcoma is an inadequate procedure; however, sometimes it cannot be avoided. The outcome of 26 patients (PTS) who underwent IL surgery for chondrosarcoma was analyzed. Median follow-up time was 146.5 months. Eighteen tumors were located in the axial skeleton and 8 in the extremities. The histologic grade distribution of the chondrosarcoma was: 14 Grade 1, 8 Grade 2, and 4 Grade 3. Diagnostic problems were noted in 4 of the 18 central tumors and 7 of 8 extremity tumors. The 20-year relapse free survival rate for the 26 PTS who underwent IL surgery was 7% and was 64% for 38 PTS who underwent wide or marginal surgery (P = 0.03144). Conversely, the 20-year overall survival rate for the 26 PTS after IL surgery was 68% and was 66% for 38 PTS who underwent wide or marginal surgery (P = 0.03144). Conversely, the 20-year overall survival rate for the 26 PTS after IL (P = 0.2266). The overall survival rates for the PTS with tumors of histologic Grade 1 and 2 or 3 tumor was 85% and 44%, respectively (P = 0.02817). The overall survival rates for PTS with central tumors and extremital tumors were 57% and 87%, respectively (P = 0.0968). IL surgery for chondrosarcoma often leads to local relapse. However,...Continue Reading

References

Nov 1, 1979·The Journal of Bone and Joint Surgery. British Volume·N G Sanerkin, P Gallagher
Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·V GöbelU Göbel
Jun 1, 1984·International Journal of Radiation Oncology, Biology, Physics·L CohenR K Ten Haken
Jan 1, 1980·Cancer·D J PritchardB E Medley

❮ Previous
Next ❯

Citations

Jul 1, 2014·World Journal of Surgical Oncology·Fei ChangJin-Cheng Wang
Aug 30, 2008·PPAR Research·K NishidaT Ozaki
Aug 31, 2010·International Orthopaedics·Philipp T FunovicsMartin Dominkus
Jul 3, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S A HannaT W R Briggs
Apr 6, 2000·Spine·S BorianiP Bacchini
Mar 7, 2013·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Domenico Andrea CampanacciRodolfo Capanna
Mar 6, 2012·Orthopedics·Andreas F MavrogenisPanayiotis J Papagelopoulos
Aug 19, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J A M BramerR M Tillman
Jun 1, 2012·Journal of Surgical Oncology·Andrea AngeliniPietro Ruggieri
May 18, 2013·Journal of Surgical Oncology·Andreas F MavrogenisPietro Ruggieri
Sep 27, 2006·The Journal of Thoracic and Cardiovascular Surgery·Hideo MoriokaYoshiaki Toyama
Oct 6, 2009·Orthopaedics & Traumatology, Surgery & Research : OTSR·X DeloinP Anract
Jun 20, 2016·Orthopaedics & Traumatology, Surgery & Research : OTSR·M Ould-SlimaneF-H Dujardin
Aug 26, 1998·International Journal of Cancer. Journal International Du Cancer·T KunisadaM Namba
Aug 26, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Gianluca FalconeGuido Fadda
Jan 15, 2009·Clinical Orthopaedics and Related Research·Chad AaronsH Thomas Temple
Sep 30, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jeff W StevensJosé A Morcuende
Jun 25, 2010·Clinical Orthopaedics and Related Research·David G MohlerRaffi S Avedian
Apr 25, 2007·Clinical Orthopaedics and Related Research·Anne N NormandAlan W Yasko
Jun 22, 2006·Clinical Orthopaedics and Related Research·Elke R AhlmannThomas Learch
May 27, 2005·Der Unfallchirurg·H SteckelR T Müller
Mar 8, 2019·The Cochrane Database of Systematic Reviews·Edwin F DierselhuisPaul C Jutte
Nov 2, 2005·The Journal of Bone and Joint Surgery. British Volume·D DonatiM Mercuri
Apr 1, 1997·Clinical Orthopaedics and Related Research·T OzakiW Winkelmann
Jan 4, 2001·Clinical Orthopaedics and Related Research·D HustedM T Scarborough
Jul 6, 2018·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ming LuStefano Boriani
Apr 13, 1999·The Journal of Bone and Joint Surgery. American Volume·F Y LeeL C Jennings
Nov 24, 2004·Clinical Orthopaedics and Related Research·Yi-Chin FongSean P Scully
Feb 17, 2017·Clinical Orthopaedics and Related Research·Tomas ZamoraEduardo Botello
Sep 4, 2004·Clinical Orthopaedics and Related Research·Michaela M SchneiderbauerSean P Scully
Oct 13, 2000·The Journal of the American Academy of Orthopaedic Surgeons·R A MarcoJ H Healey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.