Influence of intrastriatal infusion of dynorphin fragments on overflow of acetylcholine and dopamine in the rat brain

The International Journal of Neuroscience
Amar K Pani

Abstract

Dynorphin (DYN) fragments are the members of the endogenous opioid system and postulated ligands for the opioid receptors. Infusion of DYN(1-17) fragment into the rat dorsal striatum caused a significant increase in acetylcholine and decrease in dopamine overflow. Contrary to this, infusions of DYN(2-17) fragment into the rat dorsal striatum caused a significant increase in dopamine and decrease in acetylcholine overflow. Intrastriatal infusions of different doses of the acetylcholinesterase blocker, neostigmine, augmented acetylcholine and inhibited dopamine overflow in a dose-dependent manner. The opposing responses of the DYN fragments suggest that the N-terminal residue plays a key role in presynaptic neuromodulation.

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Citations

Aug 10, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mary P HeyerGuoping Feng
May 10, 2011·Physiology & Behavior·Erin N Umberg, Emmanuel N Pothos

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