PMID: 8598237Mar 1, 1996Paper

Influence of intravascular molecular weight of hydroxyethyl starch on platelets

European Journal of Haematology
J TreibK Schimrigk

Abstract

Complications concerning the blood coagulation have been observed repeatedly after administration of highly substituted, high molecular weight hydroxyethyl starch (HES), but it has not been examined as to how intravascular molecular weight and degree of substitution of HES influence platelet number and volume after repeated administration. Thirty patients with cerebrovascular diseases were treated for 10 days with hemodilution. 500 to 1500 ml of HES 200/0.62(n=10), HES 200/0.5(n=10) or HES 40/0.5(n=10) were infused daily. During the first days, the number of platelets was not lowered beyond the dilution effect, but at the end of the therapy the number of platelets had increased in all 3 groups beyond the initial value. Platelet volume was lowered significantly in the 3 groups. HES 200/0.62 caused the largest drop in platelet volume (-10%, p<0.01). A possible explanation could be that HES macromolecules are attached to platelets or are phagocytized by them. The larger platelets are then broken down and, to compensate the loss, more thrombocytes are released. A correlation between the molecular weight of HES and the breakdown rate of the platelets can be suspected, because HES 200/0.62 has the highest intravascular mean molecular...Continue Reading

References

Oct 1, 1986·Annals of Internal Medicine·B E Symington
May 1, 1987·Anesthesiology·M D CullyG D Silverberg
Oct 8, 1987·The New England Journal of Medicine·L DamonC Ries
May 1, 1988·Transfusion·R G StraussP J Villhauer
Aug 7, 1982·British Medical Journal·A EldorS Penchas

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Citations

Feb 22, 2002·Vox Sanguinis·M P W Grocott, M A Hamilton
Jun 11, 2009·Anesthesiology·Martin WestphalHugo Van Aken
Aug 28, 2014·Journal of Veterinary Emergency and Critical Care·Polly A GloverRebecca Kirby
Dec 6, 2014·Critical Care : the Official Journal of the Critical Care Forum·Matthias JacobAndrea Kurz
Sep 27, 2000·Anesthesia and Analgesia·B StögermüllerS A Kozek-Langenecker
Sep 1, 2005·Anesthesiology·Sibylle A Kozek-Langenecker
Aug 31, 2004·Anesthesia and Analgesia·Engelbert DeuschSibylle A Kozek-Langenecker
Jun 22, 2005·Clinical Pharmacokinetics·Cornelius Jungheinrich, Thomas A Neff
Dec 21, 2002·Acta Anaesthesiologica Scandinavica·M FelfernigS A Kozek-Langenecker
Jul 24, 2004·Anesthesia and Analgesia·Gary R Haynes
Oct 17, 2009·The Heart Surgery Forum·Yuksel ElaAhmet Cekirdekci
Apr 15, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Paraskevi MatsotaGeorgia Kostopanagiotou
Nov 28, 2012·American Journal of Veterinary Research·Janine ClassenKatrin Hartmann
Jun 27, 2009·Acta neurochirurgica·Ruediger GerlachKlaus Goerlinger
May 29, 2001·Anesthesia and Analgesia·A FranzS A Kozek-Langenecker
Oct 25, 2016·ChemMedChem·Søren B van WitteloostuijnKnud J Jensen
Mar 1, 1997·Journal of Neurosurgery·J Treib, A Haass
Aug 6, 2009·Best Practice & Research. Clinical Anaesthesiology·Christian ErtmerMartin Westphal
Aug 17, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Matthias LangeMartin Westphal

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