Influence of intravenous clonidine pretreatment on anesthetic requirements during bispectral EEG-guided sevoflurane anesthesia

Journal of Clinical Anesthesia
C De DeyneG Rolly


To assess the anesthetic effects of clonidine during sevoflurane anesthesia guided by the bispectral index (BIS), which is a processed EEG variable correlated with anesthetic-hypnotic depth. Placebo-controlled, double-blind clinical trial. Elective laparoscopic surgery. 60 ASA physical status I patients scheduled for laparoscopic surgery. Patients received either clonidine (3 micrograms/kg, 15 min before induction) or placebo premedication for a sevoflurane-induced and sevoflurane-maintained anesthesia. Sevoflurane was titrated against a BIS held between 40 and 50. Analgesia was provided by local infiltration with bupivacaine. Need for postoperative analgesia was recorded. Mean sevoflurane requirements were not lower with clonidine pretreatment. There was statistically better perioperative hemodynamic stability (i.e., fewer episodes of hypertension and tachycardia) without clinical relevance. A decreased need for postoperative analgesia was observed.


Mar 1, 1992·Journal of Clinical Anesthesia·M A SalonenM Maze
Jun 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·J W Flacke
Nov 1, 1987·Anesthesiology·M MazeR G Vickery
Sep 1, 1982·Anesthesia and Analgesia·B C Bloor, W E Flacke
Jan 1, 1994·Electroencephalography and Clinical Neurophysiology·M SteriadeD Contreras
Jul 1, 1994·Anesthesia and Analgesia·M OsawaK Mori
Dec 1, 1993·Anesthesiology·J F Antognini, K Schwartz
Jan 1, 1997·Acta Anaesthesiologica Scandinavica·J Kanto

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Jul 11, 2006·Current Opinion in Anaesthesiology·Arthur W Wallace
Jul 26, 2006·Anesthesia Progress·David L HallJohn D Walters
Mar 7, 2018·The Cochrane Database of Systematic Reviews·Dallas DuncanDuminda N Wijeysundera
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Duminda N WijeysunderaW Scott Beattie
Jan 20, 2012·Expert Opinion on Drug Delivery·Alejandro SosnikDiego A Chiappetta
Feb 28, 2002·Anesthesia and Analgesia·Hideyuki HiguchiTetsuo Satoh
Jan 5, 2002·Annales Françaises D'anesthèsie Et De Rèanimation·V Billard, I Constant

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