PMID: 11902646Mar 21, 2002Paper

Influence of irradiation sterilization on poly(lactide-co-glycolide) microspheres containing anti-inflammatory drugs

Il Farmaco
S CalişA Atilla Hincal

Abstract

Gamma-irradiation is finding increasing use in the sterilization of pharmaceutical products. However, irradiation might also affect the performance of drug delivery systems. In this study, the influence of gamma-irradiation on the physicochemical properties of two commonly used non-steroidal anti-inflammatory drugs (NSAIDs) [naproxen sodium (NS) and diclofenac sodium (DS)] was investigated. The drugs were incorporated in poly(lactide-co-glycolide) (PLGA, 50:50; molecular weight 34000 or 88000 Da) microspheres. The biodegradable microspheres were irradiated at doses of 5, 15, 25 kGy using a 60Co source. Drug loading of irradiated and non-irradiated microspheres with both 34000 and 88000 Da polymers were essentially the same. A significant difference was noticed in the particle sizes of the irradiated as compared to the non-irradiated formulations. Notably, in release studies, the amount of active substance released from PLGA microspheres showed an increase with increasing irradiation dose. In DSC, the glass transition temperatures (Tg) of microspheres exhibited a slow increase with irradiation dose.

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Citations

May 10, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tomasz KryczkaPaweł Grieb
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mike ClaybournChristopher C Rowlands
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Dec 18, 2015·Journal of Materials Science. Materials in Medicine·Gabriella M Fernandes-CunhaArmando Silva-Cunha
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Jan 13, 2006·Drug Delivery·Kashappa Goud Desai, Hyun Jin Park
Jun 18, 2014·Interventional Medicine & Applied Science·Gürhan Abuhanoğlu, A Yekta Ozer
May 16, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Raquel Da Costa MartinsJuan Manuel Irache
Nov 30, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A BartolottaE Calderaro
Feb 19, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Manoli IgartuaJosé Luís Pedraz
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