Influence of leukemia inhibitory factor on galanin/GMAP and neuropeptide Y expression in mouse primary sensory neurons after axotomy

Experimental Brain Research
J CornessT Hökfelt

Abstract

The effect of unilateral transection of the sciatic nerve on expression of immunoreactive galanin (GAL), galanin-message-associated peptide (GMAP) and neuropeptide tyrosine (NPY) in dorsal root ganglia (DRGs) was studied in wild-type mice and in leukemia inhibitory factor (LIF)-deficient mice. In normal and contralateral DRGs small numbers of weakly fluorescent GAL- and GMAP-positive neuronal cell bodies and numerous positive fibers were observed. No NPY-positive cell bodies but a few fibers surrounding blood vessels were seen. In LIF deficient mice hardly any GAL- or GMAP-positive neurons or fibers were seen, nor was NPY-like immunoreactivity present in cell bodies. After axotomy there was a dramatic upregulation of all three peptides in wild-type DRG neurons, whereby 50-60% of the neuron profiles, encompassing both small and large profiles, were GAL- and GMAP-immunoreactive (IR). About one third of all neuron profiles, mainly large ones, were NPY-positive. In LIF-deficient mice this upregulation was much less pronounced. Thus GAL- and GMAP-IR neuron profiles were reduced by 65-70% compared with the wild-type mice. The number of NPY-positive neuron profiles was reduced to half but this difference was not significant. There was...Continue Reading

Citations

Nov 8, 2001·European Journal of Pharmacology·Z Wiesenfeld-Hallin, X J Xu
Oct 10, 2002·Neuropeptides·Kirill V TarasovKenneth R Boheler
Jul 4, 1998·Brain Research. Brain Research Reviews·T HökfeltJ H Walsh
Feb 26, 2000·Trends in Pharmacological Sciences·T A BranchekM W Walker
Feb 13, 1999·Progress in Neurobiology·M J Millan
Mar 3, 1999·The European Journal of Neuroscience·J X HaoZ Wiesenfeld-Hallin
May 5, 1999·Journal of Anatomy·G Terenghi
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·F E HolmesD Wynick
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·A M ShadiackR E Zigmond
Nov 28, 2001·Journal of Neurotrauma·B J DowsingW A Morrison
Feb 3, 1999·Annals of the New York Academy of Sciences·M S RamerM A Bisby
Jun 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrea BaconDavid Wynick
Jan 29, 2013·Acta Neuropathologica·Shailender SinghWolfgang Brück
Jan 10, 2002·Journal of Neuroscience Research·Karin Edoff, Helena Jerregård
Dec 5, 2012·Acta histochemica·Michał BulcJarosław Całka
Jul 7, 2011·The Journal of Pain : Official Journal of the American Pain Society·Christina M SpoffordTimothy J Brennan
Jun 20, 2003·The European Journal of Neuroscience·Shinobu TamuraEmiko Senba
Dec 10, 2008·Developmental and Comparative Immunology·Patrick C HaningtonMiodrag Belosevic
Jan 16, 2007·Trends in Pharmacological Sciences·Pablo BrumovskyTomas Hökfelt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.