Influence of Lewy Pathology on Alzheimer's Disease Phenotype: A Retrospective Clinico-Pathological Study

Journal of Alzheimer's Disease : JAD
Jennifer RoudilBrainbank Neuro-CEB Neuropathology Network

Abstract

Studies have shown the frequent coexistence of Lewy pathology (LP) in Alzheimer's Disease (AD). The aim of this study was to determine the influence of LP on the clinical and cognitive phenotype in a cohort of patients with a neuropathological diagnosis of AD. We reviewed neuropathologically proven AD cases, reaching Braak stages V and VI in the brain banks of Lille and Paris between 1993 and 2016, and classified them according to LP extension (amygdala, brainstem, limbic, or neocortical). We then searched patient files for all available clinical and neuropsychiatric features and neuropsychological data. Thirty-three subjects were selected for this study, among which 16 were devoid of LP and 17 presented AD with concomitant LP. The latter were stratified into two subgroups according to LP distribution: 7 were AD with amygdala LP and 10 were AD with 'classical' (brainstem, limbic or neocortical) LP. When analyzing the incidence of each clinical feature at any point during the disease course, we found no significant difference in symptom frequency between the three groups. However, fluctuations appeared significantly earlier in patients with classical LP (2±3.5 years) than in patients without LP (7±1.7 years) or with amygdala LP ...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1996·Journal of Neuropathology and Experimental Neurology·W SamuelL A Hansen
Oct 1, 1996·The American Journal of Psychiatry·M F WeinerR N Rosenberg
Dec 13, 2000·Neurology·B DuboisB Pillon
May 2, 2003·Journal of Neuropathology and Experimental Neurology·Laura ParkkinenIrina Alafuzoff
Jul 11, 2006·Journal of Neuropathology and Experimental Neurology·Hirotake UchikadoDennis W Dickson
Dec 21, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·L M AllanR A Kenny
Nov 9, 2007·Trends in Cognitive Sciences·Elisabeth A Murray
Apr 22, 2009·Acta Neuropathologica·Charles DuyckaertsMarie-Claude Potier
May 19, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·S S WilliamsR McShane
Jan 24, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Bradley T HymanThomas J Montine
Oct 16, 2012·Brain : a Journal of Neurology·J A SchneiderD A Bennett
Jan 12, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Hiroshi YoshizawaLawrence S Honig
Dec 6, 2014·Alzheimer's Research & Therapy·Monica H BreitveDag Aarsland
Jan 6, 2015·Journal of Neural Transmission·Dietmar Rudolf ThalThomas Arzberger
May 20, 2015·JAMA Neurology·Eun Joo ChungJohn C Morris
Mar 2, 2018·Alzheimer's Research & Therapy·Alan J ThomasJohannes Attems

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Citations

Sep 4, 2019·Acta Neuropathologica Communications·Zachary A SorrentinoBenoit I Giasson
Oct 11, 2019·Annals of Clinical and Translational Neurology·Matilde BongianniGianluigi Zanusso
Oct 17, 2019·Frontiers in Pharmacology·Reena T Gottesman, Yaakov Stern
Feb 14, 2021·Journal of Alzheimer's Disease : JAD·Wim Hendricus QuintThomas Vogels
Nov 21, 2020·Alzheimer Disease and Associated Disorders·Clark FunnellMari L DeMarco
Apr 9, 2021·Journal of Neurology·Pauline OlivieriClaire Boutoleau-Bretonnière
Mar 12, 2021·Brain : a Journal of Neurology·Salvatore SpinaLea T Grinberg

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