Influence of lifestyle characteristics and VDR polymorphisms as risk factors for intervertebral disc degeneration: a case-control study

European Journal of Medical Research
Luiz Angelo VieiraLuciano Miller R Rodrigues

Abstract

Intervertebral disc degeneration (DD) is an important cause of low back pain and its precise aetiology is not fully understood, being attributed to cumulative environmental, biomechanical and genetic effects. The vitamin D plays a key role in regulation of calcium homeostasis and bone mineralization, exerting its biological activities by binding to a high-affinity receptor (VDR). Polymorphisms in VDR gene were previously associated with DD process, however with conflicting results. Here, we aimed to investigate the influence of lifestyle characteristics and VDR TaqI, BsmI, ApaI and FokI polymorphisms as risk factors for DD process. Retrospective case-control study involving 231 participants: 119 with confirmed DD and 112 healthy controls. Genotyping of VDR polymorphisms was performed by PCR-RFLP and real-time PCR using TaqMan methodology. All patients answered a questionnaire regarding lifestyle characteristics, such as educational level, pain localization, smoking habits, engagement of physical activity, postural and load weight at work and familial history of disc degeneration. The variables were compared between groups and adjusted by age and gender. The case group was composed by 52% female and 48% male and the mean age was...Continue Reading

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Citations

Feb 25, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Chenghao ZhangLachlan J Smith
Sep 16, 2020·American Journal of Physical Medicine & Rehabilitation·Rosa Giannina Castillo-AvilaSamuel Suárez-Méndez
May 23, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Rosa Giannina Castillo-AvilaNonanzit Pérez-Hernández
Aug 31, 2021·Frontiers in Genetics·Isabel PimentaFernando M Pimentel-Santos

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Methods Mentioned

BETA
genotyping
electrophoresis
PCR

Software Mentioned

Haploview
Stata

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