Influence of lignification and feruloylation of maize cell walls on the adsorption of heterocyclic aromatic amines

Journal of Agricultural and Food Chemistry
Carola FunkMirko Bunzel

Abstract

Both epidemiological and experimental data indicate that a diet rich in fiber may reduce cancer risk. One possible mechanism is by adsorbing carcinogens and transporting them out of the body without metabolic activation. We investigated the role of fiber lignification and feruloylation on the adsorption of four of the most relevant heterocyclic aromatic amines in food: 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), and 2-amino-9H-pyrido[2,3-b]indole (AalphaC). Adsorption experiments, under conditions mimicking the small intestine, were carried out using nonlignified and artificially lignified primary maize walls with defined lignin and ferulate/diferulate concentrations and defined lignin compositions. Lignin concentration and composition both influenced the adsorption of heterocyclic aromatic amines, especially the more hydrophobic types. Heterocyclic aromatic amine adsorption increased with lignin concentration. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-9H-pyrido[2,3-b]indole were better adsorbed by guaiacyl-rich lignins, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by syringyl-rich lignins, whereas...Continue Reading

Citations

Nov 3, 2016·Journal of Agricultural and Food Chemistry·Judith SchäferMirko Bunzel
Jul 19, 2017·Journal of the Science of Food and Agriculture·Judith SchäferMirko Bunzel
Jun 19, 2013·Journal of Agricultural and Food Chemistry·Piritta NiemiKaisa Poutanen
Nov 2, 2011·Journal of Agricultural and Food Chemistry·Mirko BunzelGérard Tchetseubu Saha
Oct 13, 2006·Journal of Agricultural and Food Chemistry·Mirko Bunzel, John Ralph
Feb 27, 2007·Journal of Agricultural and Food Chemistry·Carola FunkMirko Bunzel

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