PMID: 7031289Sep 1, 1981Paper

Influence of lipid infusion (0.4 g/kg/hr) and positive end expiratory pressure (8 cm H2O) on pulmonary function and hemodynamics in healthy anesthetized pigs

JPEN. Journal of Parenteral and Enteral Nutrition
H RoseggerW Hermann

Abstract

Fat emulsions are used increasingly for parenteral nutrition in premature infants suffering from various disorders, including respiratory insufficiency necessitating artificial ventilation with positive end expiratory pressure (PEEP). Both PEEP and lipid infusions (LI) may alter pulmonary hemodynamics. The simultaneous effect of LI and PEEP were therefore investigated. Five adult anesthetized Göttinger minipigs were infused with a 20% LI at a high rate of 0.4 g/kg/hr for 30 min, followed by PEEP of 8 cm H2O for 15 min. Catheters were inserted into the upper vena cava, the pulmonary artery, the right and left atrium, and the aorta, and pressures recorded continuously. Ventilation volume, respiratory fractional gas concentrations of O2 and CO2 (mass spectrometer), and blood gases were measured. The following parameters were calculated: total peripheral resistance, pulmonary arteriolar resistance, right-to-left shunt (QS/QT) dead space ventilation (VD/VT) and effective compliance. Total peripheral resistance remained unchanged. Pulmonary arteriolar resistance increased significantly during PEEP, PEEP + LI, but not during LI alone. QS/QT increased significantly during LI and returned to normal when PEEP was applied. VD/VT and effec...Continue Reading

References

Jul 1, 1977·The Journal of Pediatrics·R M NelsonD V Eitzman
Nov 1, 1975·Anesthesiology·R R KirbyD S Lederman
Feb 1, 1976·The American Journal of Clinical Nutrition·H L GreeneR Demaree
Jun 1, 1973·Journal of Applied Physiology·G SundströmM Arborelius
Nov 9, 1972·The New England Journal of Medicine·D C ShannonJ B Bunnell
Jun 1, 1973·The Journal of Pediatrics·W M Gersony
Dec 24, 1970·The New England Journal of Medicine·A KumarH Pontoppidan
Jun 17, 1971·The New England Journal of Medicine·G A GregoryW K Hamilton
Mar 1, 1969·Pediatric Research·M Winick, P Rosso
Mar 1, 1969·Pediatric Research·N R Roberton, G W Dahlenburg
Nov 1, 1960·Circulation·C R JOYNERP G WILLIAMS

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