Influence of lipid peroxidation on beta-adrenoceptors

FEBS Letters
K KramerA Bast


The peroxidation of lipids in biological membranes is a destructive phenomenon that can be elicited in various ways. Surface receptor molecules that allow cells to respond to hormones are possibly inactivated during lipid peroxidation. Effects of lipid peroxidation on receptors have not been extensively examined thus far. This investigation shows that there is a decrease in beta-adrenoceptor density (measured as specific (-)-[125I]iodocyanopindolol binding) during lipid peroxidation, in both lungs and erythrocytes of the rat. To this end, lung membranes (containing both beta 1- and beta 2-adrenoceptors) and intact erythrocytes (containing a homogeneous beta 2-adrenoceptor population) were pretreated with cumene hydroperoxide (lung membranes with 0.1 mM and erythrocytes with 1 mM) and Fe2+ (1 X 10(-5) M) for 60 min which resulted in extensive lipid peroxidation measured as malondialdehyde formation. The ration beta 1-:beta 2-adrenoceptor density in lung membranes after treatment with cumene hydroperoxide did not change and remained at 30%:70%. A single injection (i.p.) with the herbicide paraquat (50 mg/kg, 24 h), which is known to cause lung damage via lipid peroxidation, resulted in similar alterations in receptor density to t...Continue Reading


Jun 30, 1979·Toxicology and Applied Pharmacology·M Sagai, A L Tappel
Apr 23, 1985·European Journal of Pharmacology·B RademakerJ Zaagsma
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·Y SeverneG Vauquelin
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Apr 30, 1990·Biochimica Et Biophysica Acta·M BeppuK Kikugawa
Feb 1, 1993·Physiology & Behavior·K KramerA Bast
Jan 20, 1995·Journal of Chromatography. B, Biomedical Applications·A van WaardeW Vaalburg
Jan 1, 1990·Free Radical Biology & Medicine·C J Doelman, A Bast
Jan 1, 1990·Free Radical Biology & Medicine·P J Barnes
Sep 21, 2000·Transplantation Proceedings·J JuskowaK Mucha
Jan 8, 2008·Antioxidants & Redox Signaling·Hisatoshi Sugiura, Masakazu Ichinose
Mar 1, 1991·Journal of Internal Medicine·P K Ganguly
Feb 1, 1997·The Journal of Pharmacy and Pharmacology·M PairetG Engelhardt
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·R DworskiJ R Sheller
Sep 22, 2010·American Journal of Respiratory Cell and Molecular Biology·Weifeng SongSadis Matalon
Jul 1, 2002·Environmental Health and Preventive Medicine·Tetsuhito FukushimaMasaki Moriyama
Jan 1, 1990·Experimental Lung Research·C J DoelmanA Bast
Aug 1, 1988·Journal of Neurochemistry·M S Patole, T Ramasarma
Jan 11, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Magdalena ChelchowskaJerzy Leibschang
Jan 1, 1988·Free Radical Research Communications·G N BaldenkovTs S Stoytchev
Mar 31, 2004·Canadian Journal of Physiology and Pharmacology·Ron Ben-AbrahamAvi A Weinbroum
Sep 1, 1986·Chemico-biological Interactions·R LeursA Bast
May 29, 1987·Biochemical and Biophysical Research Communications·K KramerA Bast
May 7, 2002·Memórias do Instituto Oswaldo Cruz·Rosãngela Rodrigues-SilvaDelir Corrêa Gomes
Nov 4, 2017·Oxidative Medicine and Cellular Longevity·Alexandra C Sevastre-BerghianSimona V Clichici
Jan 10, 2002·Pulmonary Pharmacology & Therapeutics·P A Henricks, F P Nijkamp
Jan 1, 1993·Life Sciences·F P Nijkamp
Dec 1, 1992·Chemico-biological Interactions·A Van der Vliet, A Bast
Dec 30, 1992·Biochemical and Biophysical Research Communications·S MotojimaS Makino

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