PMID: 6162492Jan 1, 1981Paper

Influence of locally altered in vivo shear stress on aortic histamine-forming capacity and aortic albumin uptake

Blood Vessels
R A Markle, T M Hollis

Abstract

Effects of locally elevated shear stresses on thoracic histamine formation and transmural albumin uptake have been examined under in vivo conditions in anesthetized male, mongrel dogs. Results indicate that if endothelium remains intact, significant linear relationships exist between the shear intensity and aortic histamine-forming capacity and aortic content of fluorescein-labeled bovine serum albumin following 20 h of circulation time. These data suggest that in vivo the aortic (and endothelial) histidine decarboxylase system is sensitive to local alterations in applied shear stress, and that de novo aortic histamine synthesis in involved in mediating shear-induced increases in aortic transmural permeability.

Citations

Dec 1, 1993·Atherosclerosis·M H Friedman, D L Fry
Jul 7, 2007·The Journal of Surgical Research·J Scott Vanepps, David A Vorp
Aug 1, 1989·Experimental and Molecular Pathology·R A Markle
May 1, 1986·Atherosclerosis·M H FriedmanF F Mark
Jul 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G K Owens, T M Hollis
Mar 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A Orlidge, T M Hollis
Jan 13, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Heather A HimburgMorton H Friedman

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