PMID: 8607684Apr 1, 1996Paper

Influence of low-dose aprotinin on the inflammatory reaction due to cardiopulmonary bypass in children

The Annals of Thoracic Surgery
M C SeghayeG von Bernuth

Abstract

The serine protease inhibitor aprotinin inhibits trypsin, kallikrein, and plasmin and enhances the complement hemolytic activity of the first complement component C1. We tested whether low-dose aprotinin influences the inflammatory reaction related to cardiopulmonary bypass. In an open, randomized study, 25 children undergoing cardiac operations were investigated prospectively. The treated group comprised 11 patients receiving low-dose aprotinin (20,000 kIU/kg [2.8 mg/kg]), and the control group included 14 patients. Complement activation, cytokine production, and leukocyte stimulation were analyzed before, during, and after cardiopulmonary bypass. In all children, significant C3 conversion and C5a generation, interleukin-6 synthesis, and myeloperoxidase, eosinophil cationic protein, and histamine liberation occurred in relation to cardiopulmonary bypass. This was not influenced by aprotinin treatment. In contrast, neutrophil kinetic studies at the end of cardiopulmonary bypass showed a significantly lower increase in the aprotinin as compared with the control group. Our results suggest that low-dose aprotinin has little influence on the inflammatory reaction induced by cardiopulmonary bypass. Aprotinin affects neutrophil mobil...Continue Reading

References

Dec 1, 1987·The Annals of Thoracic Surgery·W van OeverenC R Wildevuur
Dec 1, 1993·The Annals of Thoracic Surgery·N E MoatA H Finn
Apr 1, 1993·The Annals of Thoracic Surgery·S Westaby
Apr 1, 1993·The Annals of Thoracic Surgery·B P BidstrupT Treasure
May 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·M C SeghayeG von Bernuth

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Citations

Dec 10, 1999·The Annals of Thoracic Surgery·N HayashidaS Aoyagi
Jun 20, 1998·British Journal of Haematology·S Bannan, P G Martin
Jan 27, 2006·The New England Journal of Medicine·Gus J Vlahakes
Feb 4, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Esther S SchoutenCasper W Bollen
Jan 13, 2010·Journal of Cardiothoracic Surgery·Efstratios E ApostolakisGeorgios S Papadopoulos
Jul 1, 1998·The Annals of Thoracic Surgery·J Boldt
Jul 1, 1998·The Annals of Thoracic Surgery·H Mössinger, W Dietrich
Jan 1, 1997·The Annals of Thoracic Surgery·S AshrafP G Martin
Jul 1, 1998·The Annals of Thoracic Surgery·P Pouard
Oct 24, 2006·Anesthesia and Analgesia·Charles W Hogue, Martin J London
Mar 20, 2008·Anesthesia and Analgesia·Michael P Eaton
Nov 6, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Thomas W Stief
Oct 4, 2006·Current Opinion in Anaesthesiology·W Dietrich
Oct 3, 2006·Current Opinion in Anaesthesiology·W T McBride, S J McBride
May 28, 2004·Perfusion·Saeed MirsadraeeCarin van Doorn
Jul 1, 2021·Seminars in Thrombosis and Hemostasis·Nadia Thrane HovgesenAnne-Mette Hvas

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