Abstract
Alterations of the normal leptin receptor (LEPR) gene may be involved in the development of obesity. Leptin has been shown to be able to modulate insulin secretion. Different polymorphisms in the LEPR gene have been studied, albeit with unclear results. The polymorphism on codon 656 produces a change in charge, making this change possibly functional. The objective of this study was to investigate the influence of Lys656Asn polymorphism in the LEPR gene on serum insulin, glucose values, and insulin resistance in the fasted state among obese men and women without diabetes mellitus. Two hundred thirty-three (body mass index, >30 kg/m(2)) nondiabetic obese patients were analyzed. Indirect calorimetry, tetrapolar electrical bioimpedance, blood pressure determination, serial assessment of nutritional intake with 3-day written food records, and biochemical analysis were performed. Statistical analysis was performed for Lys656/Asn656 and Asn656/Asn656 jointly as a mutant allelic group and for Lys656/Lys656 as a wild allelic group. The subjects' (67 males and 166 females) mean age and mean body mass index were 43.6+/-16.6 years and 35.3+/-5.6 kg/m(2), respectively. One hundred forty-three patients (61.9%) had the genotype Lys656/Lys656 ...Continue Reading
References
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Feb 15, 1996·Nature·G H LeeJ M Friedman
Jul 16, 1996·Biochemical and Biophysical Research Communications·T J KiefferJ F Habener
Sep 1, 1996·The Journal of Clinical Investigation·M W SchwartzD G Baskin
May 1, 1997·Diabetologia·L BertiH U Häring
Jun 1, 1997·Diabetes·T J KiefferJ F Habener
Apr 16, 1998·Nature·K ClémentB Guy-Grand
Aug 15, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·L OksanenK Kontula
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Mar 27, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R B CeddiaR Curi
Apr 2, 1999·Acta Paediatrica. Supplement·K Clément
Jan 25, 2000·American Journal of Physiology. Endocrinology and Metabolism·T J Kieffer, J F Habener
Apr 15, 2000·Nature·M W SchwartzD G Baskin
Jul 10, 2001·The Journal of Clinical Endocrinology and Metabolism·M WautersL Van Gaal
Dec 1, 2001·Genetics·M HeoD B Allison
May 15, 2002·Obesity Research·Machteld WautersLuc F Van Gaal
May 29, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M HeoD B Allison
Mar 27, 2004·Obesity Research·Monica MarsFrans J Kok
May 27, 2004·Diabetes·Timo A LakkaClaude Bouchard
Jun 11, 2004·Journal of Internal Medicine·M SantaniemiY A Kesäniemi
Jul 6, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T SalopuroUNKNOWN Finnish Diabetes Prevention Study Group
Citations
Mar 10, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Daniel Antonio de LuisTomas Martin
Jun 30, 2009·PloS One·Siim SõberMaris Laan
Jul 18, 2009·Archives of Medical Research·Iztiar AbeteJ Alfredo Martínez
Mar 3, 2009·Journal of Endodontics·Steven RobertsStephen W Looney
Jul 18, 2008·Diabetes Research and Clinical Practice·D A de LuisR Conde
Aug 29, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J V van Vliet-OstaptchoukN C Onland-Moret
Jun 6, 2012·Arquivos brasileiros de endocrinologia e metabologia·Natasha Favoretto DiasMarcio C Mancini
Dec 25, 2009·The Journal of Nutrition·Catherine M PhillipsHelen M Roche