Influence of macromolecule baseline on 1 H MR spectroscopic imaging reproducibility

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Rebecca BirchMartin Wilson

Abstract

Poorly characterized macromolecular (MM) and baseline artefacts are known to reduce metabolite quantitation accuracy in 1 H MR spectroscopic imaging (MRSI). Increasing echo time (TE) and improvements in MM analysis schemes have both been proposed as strategies to improve metabolite measurement reliability. In this study, the influence of TE and two MM analysis schemes on MRSI reproducibility are investigated. An experimentally acquired baseline was collected using an inversion recovery sequence (TI = 750 ms) and incorporated into the analysis method. Intrasubject reproducibility of MRSI scans, acquired at 3 Tesla, was assessed using metabolite coefficients of variance (COVs) for both experimentally acquired and simulated MM analysis schemes. In addition, the reproducibility of TE = 35 ms, 80 ms, and 144 ms was evaluated. TE = 80 ms was the most reproducible for singlet metabolites with COVs < 6% for total N-acetyl-aspartate, total creatine, and total choline; however, moderate multiplet dephasing was observed. Analysis incorporating the experimental baseline achieved higher Glu and Glx reproducibility at TE = 35 ms, and showed improvements over the simulated baseline, with higher efficacy for poorer data. Overall, TE = 80 ms yi...Continue Reading

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Citations

Sep 5, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Fan LamZhi-Pei Liang
Mar 13, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hyeong Hun Lee, Hyeonjin Kim
Aug 9, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Eva HeckovaWolfgang Bogner
Mar 7, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hyeong Hun Lee, Hyeonjin Kim
May 21, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karl LandheerChristoph Juchem
Jun 24, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michal PovažanWolfgang Bogner
Aug 17, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Martin Wilson
Nov 26, 2020·NMR in Biomedicine·Cristina CudalbuVladimír Mlynárik
Feb 28, 2021·Journal of Magnetic Resonance·Joon JangHyeonjin Kim
Aug 20, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Steve C N HuiMuhammad G Saleh

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Methods Mentioned

BETA
NMR

Software Mentioned

TARQUIN
PRESS
Python

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